PMID- 29093329
OWN - NLM
STAT- MEDLINE
DCOM- 20180614
LR  - 20180614
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 40
IP  - 11
DP  - 2017
TI  - The Emerging Picture of Mast Cell Activation: The Complex Regulatory Network of 
      High-Affinity Receptor for Immunoglobulin E Signaling.
PG  - 1828-1832
LID - 10.1248/bpb.b17-00465 [doi]
AB  - It is now well known that immunoglobulin E (IgE) and mast cells (MCs) are 
      important participants in allergic diseases. MCs contain electron-dense secretory 
      granules which are filled with inflammatory mediators. The interaction of an 
      allergen (antigen) with an antigen-specific IgE-bound high-affinity receptor for 
      IgE (FcepsilonRI) is an essential step in MC activation as well as subsequent 
      downstream signaling events. What we know is that IgE and FcepsilonRI activate a 
      complex regulatory network (i.e., signaling molecules and messengers) that 
      governs both the type of MC activation and the symptoms of allergic disease. This 
      review focuses on recent discoveries that shed new light on FcepsilonRI signaling 
      networks, holding promise for the development of new therapeutic solutions in the 
      treatment of allergic diseases.
FAU - Suzuki, Ryo
AU  - Suzuki R
AD  - Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and 
      Health Sciences, Kanazawa University.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Allergens)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Allergens/immunology/metabolism
MH  - Animals
MH  - Calcium/immunology/metabolism
MH  - Humans
MH  - Hypersensitivity/*immunology/metabolism
MH  - Immunoglobulin E/immunology/*metabolism
MH  - Mast Cells/*immunology/metabolism
MH  - Receptors, IgE/immunology/*metabolism
MH  - Signal Transduction/*immunology
OTO - NOTNLM
OT  - allergy
OT  - high-affinity immunoglobulin E receptor (Fc epsilon RI)
OT  - immunoglobulin E
OT  - mast cell
EDAT- 2017/11/03 06:00
MHDA- 2018/06/15 06:00
CRDT- 2017/11/03 06:00
PHST- 2017/11/03 06:00 [entrez]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2018/06/15 06:00 [medline]
AID - 10.1248/bpb.b17-00465 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2017;40(11):1828-1832. doi: 10.1248/bpb.b17-00465.