PMID- 29093713
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 8
DP  - 2017
TI  - Cardiac Non-Human Leukocyte Antigen Identification: Techniques and Troubles.
PG  - 1332
LID - 10.3389/fimmu.2017.01332 [doi]
LID - 1332
AB  - Historically efforts have focused on the human leukocyte antigen (HLA) as the 
      major cause for acute and chronic rejection following cardiac transplantation. 
      However, rising evidence indicates that non-HLA antibodies can be both primary 
      initiators and modifiers of antibody-mediated rejection (AMR) and cardiac 
      allograft vasculopathy (CAV). The purpose of this review is to assess currently 
      available technologies for non-HLA identification and leveraging such responses 
      toward antibody quantification. Several techniques have been used to identify 
      antigenic determinants of recipient graft-specific non-HLA humoral immune 
      responses, but each comes with its own set of benefits and caveats. Improving our 
      ability to detect non-HLA humoral immune response will aid in our understanding 
      of the underlying antigenic determinants of AMR and CAV, as well as improve 
      patient outcomes.
FAU - Gates, Katherine V
AU  - Gates KV
AD  - Department of Veterinary Medicine and Epidemiology, University of California, 
      Davis, Davis, CA, United States.
AD  - Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States.
FAU - Pereira, Naveen L
AU  - Pereira NL
AD  - Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States.
FAU - Griffiths, Leigh G
AU  - Griffiths LG
AD  - Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States.
LA  - eng
GR  - R01 HL115205/HL/NHLBI NIH HHS/United States
GR  - T35 OD010956/OD/NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20171018
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5651233
OTO - NOTNLM
OT  - antigen identification
OT  - heart transplantation
OT  - immunoproteomics
OT  - non-human leukocyte antigen antibody
OT  - proteomics
EDAT- 2017/11/03 06:00
MHDA- 2017/11/03 06:01
PMCR- 2017/01/01
CRDT- 2017/11/03 06:00
PHST- 2017/07/26 00:00 [received]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/11/03 06:00 [entrez]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2017/11/03 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2017.01332 [doi]
PST - epublish
SO  - Front Immunol. 2017 Oct 18;8:1332. doi: 10.3389/fimmu.2017.01332. eCollection 
      2017.