PMID- 29094049
OWN - NLM
STAT- MEDLINE
DCOM- 20180615
LR  - 20220408
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third 
      Millennium: A Breakthrough in Gastric Cancer.
PG  - 7869802
LID - 10.1155/2017/7869802 [doi]
LID - 7869802
AB  - INTRODUCTION: Gastric cancer is the fifth most common cancer and the third cause 
      of cancer death. The clinical outcomes of the patients are still not encouraging 
      with a low rate of 5 years' survival. Often the disease is diagnosed at advanced 
      stages and this obviously negatively affects patients outcomes. A deep 
      understanding of molecular basis of gastric cancer can lead to the identification 
      of diagnostic, predictive, prognostic, and therapeutic biomarkers. MAIN BODY: 
      This paper aims to give a global view on the molecular classification and 
      mechanisms involved in the development of the tumour and on the biomarkers for 
      gastric cancer. We discuss the role of E-cadherin, HER2, fibroblast growth factor 
      receptor (FGFR), MET, human epidermal growth factor receptor (EGFR), hepatocyte 
      growth factor receptor (HGFR), mammalian target of rapamycin (mTOR), 
      microsatellite instability (MSI), PD-L1, and TP53. We have also considered in 
      this manuscript new emerging biomarkers as matrix metalloproteases (MMPs), 
      microRNAs, and long noncoding RNAs (lncRNAs). CONCLUSIONS: Identifying and 
      validating diagnostic, prognostic, predictive, and therapeutic biomarkers will 
      have a huge impact on patients outcomes as they will allow early detection of 
      tumours and also guide the choice of a targeted therapy based on specific 
      molecular features of the cancer.
FAU - Carlomagno, Nicola
AU  - Carlomagno N
AUID- ORCID: 0000-0002-9837-5809
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Incollingo, Paola
AU  - Incollingo P
AUID- ORCID: 0000-0001-5116-1451
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Tammaro, Vincenzo
AU  - Tammaro V
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Peluso, Gaia
AU  - Peluso G
AUID- ORCID: 0000-0003-4512-4579
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Rupealta, Niccolo
AU  - Rupealta N
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Chiacchio, Gaetano
AU  - Chiacchio G
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Sandoval Sotelo, Maria Laura
AU  - Sandoval Sotelo ML
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Minieri, Gianluca
AU  - Minieri G
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Pisani, Antonio
AU  - Pisani A
AD  - Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 
      80131 Naples, Italy.
FAU - Riccio, Eleonora
AU  - Riccio E
AUID- ORCID: 0000-0002-5379-1104
AD  - Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 
      80131 Naples, Italy.
FAU - Sabbatini, Massimo
AU  - Sabbatini M
AUID- ORCID: 0000-0003-1339-9228
AD  - Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 
      80131 Naples, Italy.
FAU - Bracale, Umberto Marcello
AU  - Bracale UM
AD  - Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 
      80131 Naples, Italy.
FAU - Calogero, Armando
AU  - Calogero A
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Dodaro, Concetta Anna
AU  - Dodaro CA
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
FAU - Santangelo, Michele
AU  - Santangelo M
AUID- ORCID: 0000-0003-3046-9988
AD  - Department of Advanced Biomedical Science, University of Naples Federico II, Via 
      S. Pansini 5, 80131 Naples, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170928
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (B7-H1 Antigen)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD274 protein, human)
RN  - 0 (MicroRNAs)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.10.1 (MET protein, human)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - B7-H1 Antigen/genetics
MH  - Biomarkers, Tumor/*genetics
MH  - Humans
MH  - MicroRNAs/genetics
MH  - Microsatellite Instability
MH  - *Molecular Targeted Therapy
MH  - *Prognosis
MH  - Proto-Oncogene Proteins c-met/genetics
MH  - Receptor, ErbB-2/genetics
MH  - Stomach Neoplasms/diagnosis/*genetics/pathology/therapy
MH  - TOR Serine-Threonine Kinases/genetics
PMC - PMC5637861
EDAT- 2017/11/03 06:00
MHDA- 2018/06/16 06:00
PMCR- 2017/09/28
CRDT- 2017/11/03 06:00
PHST- 2017/04/07 00:00 [received]
PHST- 2017/07/12 00:00 [accepted]
PHST- 2017/11/03 06:00 [entrez]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2018/06/16 06:00 [medline]
PHST- 2017/09/28 00:00 [pmc-release]
AID - 10.1155/2017/7869802 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:7869802. doi: 10.1155/2017/7869802. Epub 2017 Sep 28.