PMID- 29094199
OWN - NLM
STAT- MEDLINE
DCOM- 20190425
LR  - 20210415
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Print)
IS  - 1436-6207 (Linking)
VI  - 57
IP  - 8
DP  - 2018 Dec
TI  - Relation between plasma phospholipid oleic acid and risk of heart failure.
PG  - 2937-2942
LID - 10.1007/s00394-017-1565-1 [doi]
AB  - BACKGROUND AND AIMS: Although the association between monounsaturated fatty acids 
      (MUFA) and risk factors for heart failure (HF) has been reported, it is unclear 
      whether oleic acid, the predominant MUFA in olive oil, plays a role in the 
      development of HF. Consequently, we sought to examine the relation of plasma 
      phospholipid oleic acid with HF in a male cohort. In a secondary analysis, we 
      examined the relation of the ratio of plasma monounsaturated-to-saturated fatty 
      acids (MUFA: SFA) with HF. METHODS: This prospective nested case-control study 
      was based on 788 incident HF cases and 788 controls from the Physicians' Health 
      Study. Plasma phospholipid fatty acids were measured using gas chromatography and 
      incident HF was self-reported via annual follow-up questionnaires and validated 
      in a subsample using medical records. RESULTS: The mean age was 58.7 years at 
      blood collection. In a conditional logistic regression, multivariable 
      adjusted-odds ratios (95% confidence interval) for HF across consecutive 
      quartiles of oleic acid were 1.0 (reference), 1.10 (0.79-1.54), 1.02 (0.72-1.44), 
      and 1.05 (0.72-1.54). For MUFA:SFA ratio, corresponding odds ratios (95% CI) for 
      HF were 1.0 (ref), 1.12 (0.80-1.58), 1.19 (0.84-1.68), and 0.97 (0.66-1.42). 
      CONCLUSIONS: Our data do not lend support to an association between plasma 
      phospholipid oleic acid or MUFA: SFA ratio and the risk of HF. These results 
      warrant confirmation in the general population including women and other ethnic 
      groups.
FAU - Morin, Scott J
AU  - Morin SJ
AUID- ORCID: 0000-0001-7526-2687
AD  - University of New England College of Osteopathic Medicine, Biddeford, ME, USA.
FAU - Gaziano, John M
AU  - Gaziano JM
AD  - The Massachusetts Veterans Epidemiology and Research Information Center 
      (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA, USA.
AD  - Division of Aging, Department of Medicine, Brigham and Women's Hospital and 
      Harvard Medical School, 3rd floor, 1620 Tremont Street, Boston, MA, USA.
FAU - Djousse, Luc
AU  - Djousse L
AD  - The Massachusetts Veterans Epidemiology and Research Information Center 
      (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA, USA. 
      ldjousse@rics.bwh.harvard.edu.
AD  - Division of Aging, Department of Medicine, Brigham and Women's Hospital and 
      Harvard Medical School, 3rd floor, 1620 Tremont Street, Boston, MA, USA. 
      ldjousse@rics.bwh.harvard.edu.
LA  - eng
GR  - T35 AG038027/AG/NIA NIH HHS/United States
GR  - 5T35AG038027-05/NH/NIH HHS/United States
GR  - CA-097193/NH/NIH HHS/United States
GR  - CA-40360/National Institutes of Health (US)/
GR  - CA-34944/NH/NIH HHS/United States
GR  - R01 CA097193/CA/NCI NIH HHS/United States
GR  - R01 CA034944/CA/NCI NIH HHS/United States
GR  - T35 AG026781/AG/NIA NIH HHS/United States
GR  - R01 HL034595/HL/NHLBI NIH HHS/United States
GR  - R01HL092946/NH/NIH HHS/United States
GR  - HL-26490/NH/NIH HHS/United States
GR  - HL-34595/NH/NIH HHS/United States
GR  - R01 HL026490/HL/NHLBI NIH HHS/United States
GR  - R01 CA040360/CA/NCI NIH HHS/United States
GR  - R01 HL092946/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20171101
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Olive Oil)
RN  - 0 (Phospholipids)
RN  - 2UMI9U37CP (Oleic Acid)
SB  - IM
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Fatty Acids, Monounsaturated/blood
MH  - Follow-Up Studies
MH  - Heart Failure/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oleic Acid/*blood
MH  - Olive Oil/administration & dosage
MH  - Phospholipids/*blood
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
MH  - Surveys and Questionnaires
PMC - PMC6519072
MID - NIHMS1028089
OTO - NOTNLM
OT  - Fatty acids
OT  - Heart failure
OT  - Mediterranean diet
OT  - Nutrition
OT  - Risk factor
COIS- Conflict of interest: None to declare.
EDAT- 2017/11/03 06:00
MHDA- 2019/04/26 06:00
PMCR- 2019/12/01
CRDT- 2017/11/03 06:00
PHST- 2017/06/13 00:00 [received]
PHST- 2017/10/13 00:00 [accepted]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2019/04/26 06:00 [medline]
PHST- 2017/11/03 06:00 [entrez]
PHST- 2019/12/01 00:00 [pmc-release]
AID - 10.1007/s00394-017-1565-1 [pii]
AID - 10.1007/s00394-017-1565-1 [doi]
PST - ppublish
SO  - Eur J Nutr. 2018 Dec;57(8):2937-2942. doi: 10.1007/s00394-017-1565-1. Epub 2017 
      Nov 1.