PMID- 29094268
OWN - NLM
STAT- MEDLINE
DCOM- 20180221
LR  - 20180221
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 123
IP  - 3
DP  - 2018 Mar
TI  - Comparison of intensity modulated radiotherapy with simultaneous integrated boost 
      (IMRT-SIB) and a 3-dimensional conformal parotid gland-sparing radiotherapy 
      (ConPas 3D-CRT) in treatment of nasopharyngeal carcinoma: a mono-institutional 
      experience.
PG  - 217-226
LID - 10.1007/s11547-017-0824-9 [doi]
AB  - AIM: To compare intensity modulated radiotherapy with simultaneous integrated 
      boost (IMRT-SIB) and a 3-dimensional conformal parotid gland-sparing radiotherapy 
      (ConPas 3D-CRT) in treatment of nasopharyngeal carcinoma with regard to outcomes 
      and dose distribution to the planning target volumes (PTVs) and to the organs at 
      risk (OARs). METHODS: The treatment records of 24 patients with histologically 
      proven carcinoma of the nasopharynx treated with ConPas 3D-CRT or IMRT-SIB 
      technique between May 2009 and December 2016 were assessed. RESULTS: The mean 
      dose and dose to 50% parotid glands volume as well as the maximal dose to the 
      spinal cord were significantly lower in the IMRT-SIB than in the ConPas 3-CRT 
      group (p < 0.05; p < 0.05; p < 0.01, respectively). IMRT-SIB was also superior in 
      coverage of PTVs. The 3-year overall survival (OS) and disease-free survival 
      (DFS) of patients in the IMRT-SIB and ConPas 3D-CRT groups were 77 and 81% 
      (p = 0.93), 51.9 and 70.7% (p = 0.83), respectively. CONCLUSION: IMRT-SIB 
      provided additional spearing to parotid glands and spinal cord in comparison to 
      ConPas 3D-CRT technique but without improvement of OS and DFS.
FAU - Bisof, Vesna
AU  - Bisof V
AUID- ORCID: 0000-0002-2826-9664
AD  - Department of Oncology, University Hospital Centre Zagreb, Kispaticeva 12, 
      Zagreb, Croatia. vesna.bisof@zg.t-com.hr.
AD  - School of Medicine, University of Osijek, Osijek, Croatia. 
      vesna.bisof@zg.t-com.hr.
FAU - Rakusic, Zoran
AU  - Rakusic Z
AD  - Department of Oncology, University Hospital Centre Zagreb, Kispaticeva 12, 
      Zagreb, Croatia.
AD  - School of Medicine, University of Zagreb, Zagreb, Croatia.
FAU - Bibic, Juraj
AU  - Bibic J
AD  - Department of Oncology, University Hospital Centre Zagreb, Kispaticeva 12, 
      Zagreb, Croatia.
FAU - Grego, Timor
AU  - Grego T
AD  - Department of Oncology, University Hospital Centre Zagreb, Kispaticeva 12, 
      Zagreb, Croatia.
FAU - Soce, Majana
AU  - Soce M
AD  - Department of Oncology, University Hospital Centre Zagreb, Kispaticeva 12, 
      Zagreb, Croatia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20171101
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
MH  - Carcinoma/*radiotherapy
MH  - Disease-Free Survival
MH  - Humans
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Nose Neoplasms
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiotherapy, Conformal/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
OTO - NOTNLM
OT  - Nasopharyngeal cancer
OT  - Organs at risk
OT  - Radiotherapy
OT  - Treatment techniques
EDAT- 2017/11/03 06:00
MHDA- 2018/02/22 06:00
CRDT- 2017/11/03 06:00
PHST- 2017/06/17 00:00 [received]
PHST- 2017/10/09 00:00 [accepted]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2018/02/22 06:00 [medline]
PHST- 2017/11/03 06:00 [entrez]
AID - 10.1007/s11547-017-0824-9 [pii]
AID - 10.1007/s11547-017-0824-9 [doi]
PST - ppublish
SO  - Radiol Med. 2018 Mar;123(3):217-226. doi: 10.1007/s11547-017-0824-9. Epub 2017 
      Nov 1.