PMID- 29094298
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 8
IP  - 6
DP  - 2017 Dec
TI  - Optimizing Glycemic Control Through Titration of Insulin Glargine 100 U/mL: A 
      Review of Current and Future Approaches with a Focus on Asian Populations.
PG  - 1197-1214
LID - 10.1007/s13300-017-0322-z [doi]
AB  - Various data have demonstrated inadequate glycemic control amongst Asians with 
      type 2 diabetes mellitus (T2DM), possibly on account of suboptimal titration of 
      basal insulin-an issue which needs to be further examined. Here we review the 
      available global and Asia-specific data on titration of basal insulin, with a 
      focus on the use of insulin glargine 100 U/mL (Gla-100). We also discuss clinical 
      evidence on the efficacy and safety of titrating Gla-100, different approaches to 
      titration, including some of the latest technological advancements, and guidance 
      on the titration of basal insulin from international and local Asian guidelines. 
      The authors also provide their recommendations for the initiation and titration 
      of basal insulin for Asian populations. Discussion of the data included in this 
      review and in relation to the authors' clinical experience with treating T2DM in 
      Asian patients is also included. Briefly, clinical studies demonstrate the 
      achievement of adequate glycemic control in adults with T2DM through titration of 
      Gla-100. However, studies investigating approaches to titration, specifically in 
      Asian populations, are lacking and need to be conducted. Given that the 
      management of insulin therapy is a multidisciplinary team effort involving 
      endocrinologists, primary care physicians, nurse educators, and patients, greater 
      resources and education targeted at these groups are needed regarding the optimal 
      titration of basal insulin. Technological advancements in the form of mobile or 
      web-based applications for automated dose adjustment can aid different 
      stakeholders in optimizing the dose of basal insulin, enabling a larger number of 
      patients in Asia to reach their target glycemic goals with improved outcomes.
FAU - Deerochanawong, Chaicharn
AU  - Deerochanawong C
AD  - Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand. 
      chaichan@health.moph.go.th.
FAU - Bajpai, Shailendra
AU  - Bajpai S
AD  - , Sanofi, Singapore.
FAU - Dwipayana, I Made Pande
AU  - Dwipayana IMP
AD  - Faculty of Medicine, Udayana University, Bali, Indonesia.
FAU - Hussein, Zanariah
AU  - Hussein Z
AD  - Department of Medicine, Putrajaya Hospital, Putrajaya, Malaysia.
FAU - Mabunay, Maria Aileen
AU  - Mabunay MA
AD  - , Sanofi, Singapore.
FAU - Rosales, Reynaldo
AU  - Rosales R
AD  - St. Luke's Medical Center, Manila, Philippines.
FAU - Tsai, Shih-Tzer
AU  - Tsai ST
AD  - Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Tsang, Man Wo
AU  - Tsang MW
AD  - United Medical Practice, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171101
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC5688987
OTO - NOTNLM
OT  - Asia
OT  - Basal insulin
OT  - Dose optimization
OT  - Dose titration
OT  - Insulin glargine 100 U/mL
OT  - Type 2 diabetes mellitus
EDAT- 2017/11/03 06:00
MHDA- 2017/11/03 06:01
PMCR- 2017/11/01
CRDT- 2017/11/03 06:00
PHST- 2017/07/19 00:00 [received]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2017/11/03 06:01 [medline]
PHST- 2017/11/03 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 10.1007/s13300-017-0322-z [pii]
AID - 322 [pii]
AID - 10.1007/s13300-017-0322-z [doi]
PST - ppublish
SO  - Diabetes Ther. 2017 Dec;8(6):1197-1214. doi: 10.1007/s13300-017-0322-z. Epub 2017 
      Nov 1.