PMID- 29094366
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20180911
IS  - 1468-2494 (Electronic)
IS  - 0142-5463 (Linking)
VI  - 40
IP  - 1
DP  - 2018 Feb
TI  - Observer-blind randomized controlled study of a cosmetic blend of safflower, 
      olive and other plant oils in the improvement of scar and striae appearance.
PG  - 81-86
LID - 10.1111/ics.12438 [doi]
AB  - OBJECTIVE: The normal process of skin tissue repair following injury invariably 
      results in visual scarring. It is known that topical treatment with hydrophobic 
      cosmetics rich in silicone and mineral oil content can improve the appearance of 
      scars and striae. Given lifestyle preferences of many cosmetic consumers towards 
      so-called natural treatments, the objective of this controlled randomized study 
      was to investigate the efficacy of a plant body oil rich in oleic and linoleic 
      acids (Bio Skin Oil((R)) ) for improving the appearance of scars and striae. 
      METHODS: A panel of 80 volunteers with non-hypertrophic scars (40) or stretch 
      marks (40) not older than 3 years applied a cosmetic face and body oil for 8 
      weeks. Compared to an untreated scar/stretch mark region, a blinded investigator 
      as well as volunteer assessments with given observed parameters demonstrated the 
      efficacy of the oil under test. RESULTS: On the Observer Scar Assessment Scale 
      (OSAS), the mean score was reduced on the product-treated area by approximately 
      5% (P = 0.006). The untreated area remained unchanged. Observed effects by 
      volunteers were more pronounced - Patient Scar Assessment Scale (PSAS) giving a 
      reduction of approximately 20% on the treated area, and on the control untreated 
      area a reduction of approximately 6%. The overall product effect of 14% was shown 
      to be clearly significant (P = 0.001). All statements relating to product traits 
      achieved higher frequencies of agreements than of non-agreements and were 
      therefore assessed positively by the volunteers. Highest frequencies of 
      agreements occurred in statements that the test product provides a long-lasting, 
      soft and supple skin feeling (93%); caring effect (87%); and quick absorbance 
      (84%). Agreement was also found for statements that the product improves the skin 
      appearance (61%) and that scars/striae appear less pronounced (51%). Only 17% of 
      volunteers felt the oil had no benefit to the appearance of their scars/striae. 
      CONCLUSIONS: The oil blend under test is effective in improving the appearance of 
      non-keloid scars and striae. Further work is required to understand the 
      mechanisms of how plant oil fatty acids ameliorate scar and striae appearance.
CI  - (c) 2017 proDERM Institute for Applied Dermatological Research GmbH. International 
      Journal of Cosmetic Science published by John Wiley & Sons Ltd on behalf of 
      Society of Cosmetic Scientists and the Societe Francaise de Cosmetologie.
FAU - Bielfeldt, S
AU  - Bielfeldt S
AD  - proDERM, Institute for Applied Dermatological Research GmbH, Kiebitzweg 2, 
      Schenefeld/Hamburg, DE 22869, Germany.
FAU - Blaak, J
AU  - Blaak J
AD  - Kneipp GmbH, Research & Development, Winterhauser Str. 85, Wurzburg, DE 97084, 
      Germany.
FAU - Staib, P
AU  - Staib P
AD  - Kneipp GmbH, Research & Development, Winterhauser Str. 85, Wurzburg, DE 97084, 
      Germany.
FAU - Simon, I
AU  - Simon I
AD  - Kneipp GmbH, Research & Development, Winterhauser Str. 85, Wurzburg, DE 97084, 
      Germany.
FAU - Wohlfart, R
AU  - Wohlfart R
AD  - Kneipp GmbH, Research & Development, Winterhauser Str. 85, Wurzburg, DE 97084, 
      Germany.
FAU - Manger, C
AU  - Manger C
AUID- ORCID: 0000-0001-8505-5761
AD  - proDERM, Institute for Applied Dermatological Research GmbH, Kiebitzweg 2, 
      Schenefeld/Hamburg, DE 22869, Germany.
FAU - Wilhelm, K P
AU  - Wilhelm KP
AD  - proDERM, Institute for Applied Dermatological Research GmbH, Kiebitzweg 2, 
      Schenefeld/Hamburg, DE 22869, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20171212
PL  - England
TA  - Int J Cosmet Sci
JT  - International journal of cosmetic science
JID - 8007161
RN  - 0 (Cosmetics)
RN  - 0 (Olive Oil)
RN  - 0 (Plant Oils)
RN  - 8001-23-8 (Safflower Oil)
SB  - IM
MH  - Adult
MH  - Cicatrix/*therapy
MH  - *Cosmetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Olive Oil/administration & dosage/therapeutic use
MH  - Plant Oils/administration & dosage/*therapeutic use
MH  - Safflower Oil/administration & dosage/therapeutic use
MH  - Striae Distensae/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - POSAS score
OT  - claim substantiation
OT  - formulation hair + body care
OT  - plant oils
OT  - scars/striae
OT  - skin physiology/structure
EDAT- 2017/11/03 06:00
MHDA- 2018/09/12 06:00
CRDT- 2017/11/03 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2017/10/25 00:00 [accepted]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2017/11/03 06:00 [entrez]
AID - 10.1111/ics.12438 [doi]
PST - ppublish
SO  - Int J Cosmet Sci. 2018 Feb;40(1):81-86. doi: 10.1111/ics.12438. Epub 2017 Dec 12.