PMID- 29094448
OWN - NLM
STAT- MEDLINE
DCOM- 20190730
LR  - 20190730
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 17
IP  - 1
DP  - 2018 Feb
TI  - Amyloid Beta monomers regulate cyclic adenosine monophosphate response element 
      binding protein functions by activating type-1 insulin-like growth factor 
      receptors in neuronal cells.
LID - 10.1111/acel.12684 [doi]
LID - e12684
AB  - Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated 
      with synaptic dysfunction, pathological accumulation of beta-amyloid (Abeta), and 
      neuronal loss. The self-association of Abeta monomers into soluble oligomers seems 
      to be crucial for the development of neurotoxicity (J. Neurochem., 00, 2007 and 
      1172). Abeta oligomers have been suggested to compromise neuronal functions in AD by 
      reducing the expression levels of the CREB target gene and brain-derived 
      neurotrophic factor (BDNF) (J. Neurosci., 27, 2007 and 2628; Neurobiol. Aging, 
      36, 2015 and 20406 Mol. Neurodegener., 6, 2011 and 60). We previously reported a 
      broad neuroprotective activity of physiological Abeta monomers, involving the 
      activation of type-1 insulin-like growth factor receptors (IGF-IRs) (J. 
      Neurosci., 29, 2009 and 10582, Front Cell Neurosci., 9, 2015 and 297). We now 
      provide evidence that Abeta monomers, by activating the IGF-IR-stimulated PI3-K/AKT 
      pathway, induce the activation of CREB in neurons and sustain BDNF transcription 
      and release.
CI  - (c) 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley 
      & Sons Ltd.
FAU - Zimbone, Stefania
AU  - Zimbone S
AD  - Institute of Biostructures and Bioimaging, National Council of Research 
      (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
FAU - Monaco, Irene
AU  - Monaco I
AD  - Institute of Biostructures and Bioimaging, National Council of Research 
      (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
FAU - Giani, Fiorenza
AU  - Giani F
AD  - Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima 
      Medical Center, University of Catania, via Palermo 636, 95122, Catania, Italy.
FAU - Pandini, Giuseppe
AU  - Pandini G
AD  - Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima 
      Medical Center, University of Catania, via Palermo 636, 95122, Catania, Italy.
FAU - Copani, Agata G
AU  - Copani AG
AD  - Institute of Biostructures and Bioimaging, National Council of Research 
      (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
AD  - Department of Drug Sciences, University of Catania, Viale A. Doria 6, 95125, 
      Catania, Italy.
FAU - Giuffrida, Maria Laura
AU  - Giuffrida ML
AD  - Institute of Biostructures and Bioimaging, National Council of Research 
      (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
FAU - Rizzarelli, Enrico
AU  - Rizzarelli E
AD  - Institute of Biostructures and Bioimaging, National Council of Research 
      (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
AD  - Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125, 
      Catania, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171101
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IGF1R protein, human)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Somatomedin)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
MH  - Alzheimer Disease/pathology
MH  - Amyloid beta-Peptides/metabolism/*pharmacology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/drug effects/genetics
MH  - Gene Expression Regulation/*drug effects
MH  - Humans
MH  - Neurons/*drug effects/metabolism
MH  - Peptide Fragments/metabolism
MH  - Rats
MH  - Receptor, IGF Type 1/*drug effects/genetics
MH  - Receptors, Somatomedin/drug effects
MH  - Signal Transduction/drug effects
PMC - PMC5770784
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Abeta monomers
OT  - BDNF
OT  - CREB
OT  - IGF1-R
EDAT- 2017/11/03 06:00
MHDA- 2019/07/31 06:00
PMCR- 2018/02/01
CRDT- 2017/11/03 06:00
PHST- 2017/08/28 00:00 [accepted]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2019/07/31 06:00 [medline]
PHST- 2017/11/03 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - ACEL12684 [pii]
AID - 10.1111/acel.12684 [doi]
PST - ppublish
SO  - Aging Cell. 2018 Feb;17(1):e12684. doi: 10.1111/acel.12684. Epub 2017 Nov 1.