PMID- 29095094
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20180202
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 93
IP  - 12
DP  - 2017 Dec
TI  - Melatonin prevents possible radiotherapy-induced thyroid injury.
PG  - 1350-1356
LID - 10.1080/09553002.2017.1397296 [doi]
AB  - PURPOSE: We aimed to investigate the protective effect of melatonin in 
      radiotherapy-induced thyroid gland injury in an experimental rat model. MATERIALS 
      AND METHODS: Thirty-two rats were divided into four groups: the control group, 
      melatonin treatment group, radiotherapy group and melatonin plus radiotherapy 
      group. The neck region of each rat was defined by simulation and radiated with 2 
      Gray (Gy) per min with 6-MV photon beams, for a total dose of 18 Gy. Melatonin 
      was administered at a dose of 50 mg/kg through intraperitoneal injection, 15 min 
      prior to radiation exposure. Thirty days after the beginning of the study, rats 
      were decapitated and analyses of blood and thyroid tissue were performed. 
      RESULTS: Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), 
      thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels in 
      the radiotherapy group were significantly higher than those in the melatonin plus 
      radiotherapy group (p < .05), whereas interleukin-10 (IL-10) and glutathione 
      (GSH) values were higher in the melatonin plus radiotherapy group (p < .05). The 
      infiltration of inflammatory cells and percentage of apoptosis in the 
      radiotherapy group were significantly higher than those in the melatonin plus 
      radiotherapy group (p < .05). CONCLUSIONS: Melatonin helped protect thyroid gland 
      structure against the undesired cytotoxic effects of radiotherapy in rats.
FAU - Aricigil, Mitat
AU  - Aricigil M
AUID- ORCID: 0000-0001-7004-1367
AD  - a Department of Otorhinolaryngology , Meram Faculty of Medicine, Necmettin 
      Erbakan University , Konya , Turkey.
FAU - Dundar, Mehmet Akif
AU  - Dundar MA
AD  - a Department of Otorhinolaryngology , Meram Faculty of Medicine, Necmettin 
      Erbakan University , Konya , Turkey.
FAU - Yucel, Abitter
AU  - Yucel A
AD  - b Department of Otorhinolaryngology , Horasan State Hospital , Erzurum , Turkey.
FAU - Eryilmaz, Mehmet Akif
AU  - Eryilmaz MA
AD  - a Department of Otorhinolaryngology , Meram Faculty of Medicine, Necmettin 
      Erbakan University , Konya , Turkey.
FAU - Aktan, Meryem
AU  - Aktan M
AD  - c Department of Radiation Oncology , Meram Faculty of Medicine, Necmettin Erbakan 
      University , Konya , Turkey.
FAU - Alan, Mehmet Akif
AU  - Alan MA
AD  - a Department of Otorhinolaryngology , Meram Faculty of Medicine, Necmettin 
      Erbakan University , Konya , Turkey.
FAU - Findik, Sidika
AU  - Findik S
AD  - d Department of Pathology , Meram Faculty of Medicine, Necmettin Erbakan 
      University , Konya , Turkey.
FAU - Kilinc, Ibrahim
AU  - Kilinc I
AD  - e Department of Medical Biochemistry , Meram Faculty of Medicine, Necmettin 
      Erbakan University , Konya , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20171120
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Antioxidants)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Oxidants)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Female
MH  - Interleukin-10/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Melatonin/*pharmacology
MH  - Oxidants/metabolism
MH  - Radiation Injuries, Experimental/metabolism/pathology/*prevention & control
MH  - Rats
MH  - Rats, Wistar
MH  - Thyroid Gland/*drug effects/metabolism/pathology/*radiation effects
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Melatonin
OT  - apoptosis
OT  - inflammation
OT  - radiotherapy
OT  - thyroid
EDAT- 2017/11/03 06:00
MHDA- 2017/12/12 06:00
CRDT- 2017/11/03 06:00
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
PHST- 2017/11/03 06:00 [entrez]
AID - 10.1080/09553002.2017.1397296 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2017 Dec;93(12):1350-1356. doi: 10.1080/09553002.2017.1397296. 
      Epub 2017 Nov 20.