PMID- 29095875 OWN - NLM STAT- MEDLINE DCOM- 20171204 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 11 DP - 2017 TI - Trajectories of positive, negative and general psychopathology symptoms in first episode psychosis and their relationship with functioning over a 2-year follow-up period. PG - e0187141 LID - 10.1371/journal.pone.0187141 [doi] LID - e0187141 AB - BACKGROUND: Few studies have examined the trajectories of symptom severity in first episode psychosis (FEP) and their impact on functioning. This study aimed to identify discrete trajectories of positive, negative and general psychopathological symptoms and functioning, determine predictors of the identified symptom trajectories and subsequently investigate the relationship between symptom and functioning trajectories over the 2-year follow-up period. METHODS: Data were extracted from the Singapore Early Psychosis Intervention Programme clinical database. Trajectories of the Positive and Negative Syndrome Scale and Global Assessment of Functioning (GAF) scale over the two-year follow up were modelled using latent class growth curve modelling. RESULTS: Two distinct trajectories (early response and stable trajectory and delayed response trajectory) for positive symptoms, four distinct trajectories (early response and stable trajectory, early response and relapse trajectory, slower response and no response trajectory and delayed response trajectory) for negative and general psychopathology symptoms and three distinct trajectories for functioning (high functioning trajectory, moderately stable functioning trajectory and deterioration in functioning trajectory) were identified in our sample. Compared to individuals in the early response and stable trajectory, those in the delayed response trajectory for positive and negative symptoms, early response and relapse for negative and general psychopathology symptoms and slower response and no response trajectories for general psychopathology symptoms were significantly associated with higher odds of having deterioration in functioning over time. Poor symptom trajectories were also significantly predicted by younger age, male gender, unemployed and economically inactive status, lower education, longer duration of untreated psychosis and diagnosis of schizophrenia spectrum and delusional disorders. CONCLUSIONS: The results confirm that the symptoms trajectories among patients with FEP are heterogeneous and suggest that a small group of patients may be at higher risk of deterioration in symptom severity and functioning over the 2-year follow-up. FAU - Abdin, Edimansyah AU - Abdin E AUID- ORCID: 0000-0002-1016-3298 AD - Research Division, Institute of Mental Health, Singapore. FAU - Chong, Siow Ann AU - Chong SA AD - Research Division, Institute of Mental Health, Singapore. FAU - Vaingankar, Janhavi Ajit AU - Vaingankar JA AD - Research Division, Institute of Mental Health, Singapore. FAU - Peh, Chao Xu AU - Peh CX AD - Research Division, Institute of Mental Health, Singapore. FAU - Poon, Lye Yin AU - Poon LY AD - Department of Early Psychosis Intervention, Institute of Mental Health, Singapore. FAU - Rao, Sujatha AU - Rao S AD - Department of Early Psychosis Intervention, Institute of Mental Health, Singapore. FAU - Verma, Swapna AU - Verma S AD - Department of Early Psychosis Intervention, Institute of Mental Health, Singapore. FAU - Subramaniam, Mythily AU - Subramaniam M AD - Research Division, Institute of Mental Health, Singapore. LA - eng PT - Journal Article DEP - 20171102 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - *Psychopathology MH - Psychotic Disorders/*psychology MH - Singapore MH - Young Adult PMC - PMC5667842 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2017/11/03 06:00 MHDA- 2017/12/05 06:00 PMCR- 2017/11/02 CRDT- 2017/11/03 06:00 PHST- 2017/03/16 00:00 [received] PHST- 2017/10/14 00:00 [accepted] PHST- 2017/11/03 06:00 [entrez] PHST- 2017/11/03 06:00 [pubmed] PHST- 2017/12/05 06:00 [medline] PHST- 2017/11/02 00:00 [pmc-release] AID - PONE-D-17-10361 [pii] AID - 10.1371/journal.pone.0187141 [doi] PST - epublish SO - PLoS One. 2017 Nov 2;12(11):e0187141. doi: 10.1371/journal.pone.0187141. eCollection 2017.