PMID- 29097274
OWN - NLM
STAT- MEDLINE
DCOM- 20190618
LR  - 20190618
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 55
IP  - 3
DP  - 2018 Mar
TI  - Minimal Clinically Important Difference of the Multidimensional Fatigue Symptom 
      Inventory-Short Form (MFSI-SF) for Fatigue Worsening in Asian Breast Cancer 
      Patients.
PG  - 992-997.e2
LID - S0885-3924(17)30594-8 [pii]
LID - 10.1016/j.jpainsymman.2017.10.014 [doi]
AB  - CONTEXT: The minimal clinically important difference (MCID) of the 
      Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), a questionnaire 
      that measures cancer-related fatigue, has not been established in patients with 
      cancer. OBJECTIVES: This study aims to determine the MCID of the MFSI-SF. 
      METHODS: Breast cancer patients completed the MFSI-SF and the European 
      Organization for Research and Treatment of Cancer Quality of Life 
      Questionnaire-Core 30 (EORTC-QLQ-C30) before chemotherapy and at least three 
      weeks later. The EORTC-QLQ-C30 fatigue scale (EORTC-FA) was used as an anchor, 
      and a receiver operating characteristic (ROC) curve was also used to identify the 
      optimal MCID cut-off for fatigue deterioration. A distribution-based approach 
      used one-third of the SD, half of the SD, and one SEM of the total MFSI-SF score 
      to determine the MCID. RESULTS: A total of 201 patients were analyzed. Change 
      scores of the MFSI-SF and EORTC-FA were moderately correlated (r = 0.47, 
      P < 0.001). The EORTC-FA-anchored MCID was 8.69 points (95% CI: 4.03-13.34). The 
      MCID attained from the ROC curve method was 4.50 points (sensitivity: 68.8%; 
      specificity: 64.1%). For the distribution-based approach, the MCIDs corresponding 
      to one-third of the SD, half of the SD, and one SEM were 5.39, 8.99, and 10.79 
      points, respectively. CONCLUSION: The MCID of the MFSI-SF identified by all 
      approaches ranged from 4.50 to 10.79 points. The MCID can be used to interpret 
      the clinical significance of fatigue deterioration in patients with breast cancer 
      and to determine sample sizes for future clinical trials.
CI  - Copyright (c) 2017 American Academy of Hospice and Palliative Medicine. Published 
      by Elsevier Inc. All rights reserved.
FAU - Chan, Alexandre
AU  - Chan A
AD  - Department of Pharmacy, National University of Singapore, Singapore; Department 
      of Pharmacy, National Cancer Centre Singapore, Singapore. Electronic address: 
      phaac@nus.edu.sg.
FAU - Yo, Tiffany Eri
AU  - Yo TE
AD  - Department of Pharmacy, National University of Singapore, Singapore.
FAU - Wang, Xiao Jun
AU  - Wang XJ
AD  - Department of Pharmacy, National University of Singapore, Singapore; Department 
      of Pharmacy, National Cancer Centre Singapore, Singapore.
FAU - Ng, Terence
AU  - Ng T
AD  - Department of Pharmacy, National University of Singapore, Singapore; Department 
      of Pharmacy, National Cancer Centre Singapore, Singapore.
FAU - Chae, Jung-Woo
AU  - Chae JW
AD  - Department of Pharmacy, National University of Singapore, Singapore; Department 
      of Pharmacy, National Cancer Centre Singapore, Singapore.
FAU - Yeo, Hui Ling
AU  - Yeo HL
AD  - Department of Pharmacy, National University of Singapore, Singapore.
FAU - Shwe, Maung
AU  - Shwe M
AD  - Department of Pharmacy, National University of Singapore, Singapore.
FAU - Gan, Yan Xiang
AU  - Gan YX
AD  - Department of Pharmacy, National Cancer Centre Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171031
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Breast Neoplasms/complications/*diagnosis/drug therapy
MH  - Fatigue/*diagnosis/*etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Prospective Studies
MH  - ROC Curve
OTO - NOTNLM
OT  - European Organization for Research and Treatment of Cancer Quality of Life 
      Questionnaire-Core 30
OT  - Minimal clinically important difference
OT  - Multidimensional Fatigue Symptom Inventory-Short Form
OT  - breast cancer
EDAT- 2017/11/04 06:00
MHDA- 2019/06/19 06:00
CRDT- 2017/11/04 06:00
PHST- 2017/06/29 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/10/23 00:00 [accepted]
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2019/06/19 06:00 [medline]
PHST- 2017/11/04 06:00 [entrez]
AID - S0885-3924(17)30594-8 [pii]
AID - 10.1016/j.jpainsymman.2017.10.014 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2018 Mar;55(3):992-997.e2. doi: 
      10.1016/j.jpainsymman.2017.10.014. Epub 2017 Oct 31.