PMID- 29097844
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 0914-9198 (Print)
IS  - 1881-915X (Electronic)
IS  - 0914-9198 (Linking)
VI  - 30
IP  - 4
DP  - 2017 Oct
TI  - Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) 
      pathway of the DNA damage response in the brain of rats administered arsenic 
      trioxide.
PG  - 333-337
LID - 10.1293/tox.2017-0020 [doi]
AB  - To examine the in vivo responses of promyelocytic leukemia protein (PML) to 
      arsenic, rats (male, 6 weeks old, Sprague Dawley) were administered a single 
      intraperitoneal dose of 5 mg/kg arsenic trioxide (ATO). The protein was examined 
      in the heart, lung, liver, and brain 6 and 48 hours after administration: a 
      significant response of PML was observed in the brain. Oxidative DNA modification 
      was also observed in the brain as revealed by increased immunoreactivity to 
      anti-8-hydroxy-2'-deoxyguanosine (8-OHdG) antibody. In contrast, terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) stain 
      reactivity was only slightly increased, suggesting oxidative cellular stress 
      without apoptotic cell death in the ATO-administered rat brain. Among the DNA 
      damage response pathways, the ATR-Chk1 axis was activated, while the ATM-Chk2 
      axis was not, implying that the PML response is associated with activation of the 
      ATR-Chk1 DNA repair pathway in the brain.
FAU - Watanabe, Ryo
AU  - Watanabe R
AD  - Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, 
      Japan.
FAU - Unuma, Kana
AU  - Unuma K
AD  - Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, 
      Japan.
FAU - Noritake, Kanako
AU  - Noritake K
AD  - Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, 
      Japan.
FAU - Funakoshi, Takeshi
AU  - Funakoshi T
AD  - Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, 
      Japan.
FAU - Aki, Toshihiko
AU  - Aki T
AD  - Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, 
      Japan.
FAU - Uemura, Koichi
AU  - Uemura K
AD  - Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20170703
PL  - Japan
TA  - J Toxicol Pathol
JT  - Journal of toxicologic pathology
JID - 9306408
PMC - PMC5660956
OTO - NOTNLM
OT  - DNA damage
OT  - arsenic trioxide
OT  - ataxia telangiectasia and rad3 related
OT  - brain
OT  - promyelocytic leukemia protein
EDAT- 2017/11/04 06:00
MHDA- 2017/11/04 06:01
PMCR- 2017/10/01
CRDT- 2017/11/04 06:00
PHST- 2017/03/15 00:00 [received]
PHST- 2017/05/12 00:00 [accepted]
PHST- 2017/11/04 06:00 [entrez]
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2017/11/04 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - 2017-0020 [pii]
AID - 10.1293/tox.2017-0020 [doi]
PST - ppublish
SO  - J Toxicol Pathol. 2017 Oct;30(4):333-337. doi: 10.1293/tox.2017-0020. Epub 2017 
      Jul 3.