PMID- 29098408
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20220410
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 33
IP  - 4
DP  - 2018 Apr
TI  - Increased serum Wisteria floribunda agglutinin positive Mac-2 binding protein 
      (Mac-2 binding protein glycosylation isomer) in chronic heart failure: a pilot 
      study.
PG  - 385-392
LID - 10.1007/s00380-017-1071-7 [doi]
AB  - BACKGROUND: Serum Wisteria floribunda agglutinin positive Mac-2 binding protein 
      (WFA(+)-M2BP) or Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel 
      biomarker currently applied for evaluating hepatic fibrosis. The aim of this 
      study was to evaluate the utility of serum WFA(+)-M2BP level as a biomarker in 
      chronic heart failure (HF) patients with abnormal liver function. METHODS AND 
      RESULTS: Fifty chronic HF patients who underwent measurement of serum WFA(+)-M2BP 
      were evaluated. The median value of serum WFA(+)-M2BP was 0.88 (interquartile 
      range 0.48-1.29) cut-off index, and positive WFA(+)-M2BP (>/= 1.00 cut-off index) 
      was observed in 22 (44%). Elevated WFA + -M2BP was associated with longer HF 
      history, older age, female sex, valvular heart disease, decreased estimated 
      glomerular filtration rate (eGFR), albumin, and cholinesterase. Stepwise multiple 
      regression analysis showed that HF history, eGFR, and albumin were independent 
      determinants of serum WFA(+)-M2BP values. Repeated measurements of serum 
      WFA(+)-M2BP suggested association between the decrease of WFA(+)-M2BP and 
      improvement of New York Heart Association (NYHA) functional class. CONCLUSIONS: 
      Elevation of serum WFA(+)-M2BP showed a high prevalence in chronic HF patients 
      with abnormal liver function with relation to HF history, decreased hepatic 
      protein synthesis, and renal dysfunction. Our results suggest that serum 
      WFA(+)-M2BP may be a novel biomarker of chronic HF.
FAU - Okada, Atsushi
AU  - Okada A
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
AD  - Department of Advanced Cardiovascular Medicine, Graduate School of Medical 
      Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Kanzaki, Hideaki
AU  - Kanzaki H
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan. kanzakih@ncvc.go.jp.
FAU - Hamatani, Yasuhiro
AU  - Hamatani Y
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
FAU - Takashio, Seiji
AU  - Takashio S
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
FAU - Takahama, Hiroyuki
AU  - Takahama H
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
FAU - Amaki, Makoto
AU  - Amaki M
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
FAU - Hasegawa, Takuya
AU  - Hasegawa T
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
FAU - Sugano, Yasuo
AU  - Sugano Y
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
FAU - Yasuda, Satoshi
AU  - Yasuda S
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
AD  - Department of Advanced Cardiovascular Medicine, Graduate School of Medical 
      Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Anzai, Toshihisa
AU  - Anzai T
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
AD  - Department of Advanced Cardiovascular Medicine, Graduate School of Medical 
      Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
LA  - eng
GR  - 28-6-18/National Cerebral and Cardiovascular Center/
PT  - Journal Article
DEP - 20171102
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Plant Lectins)
RN  - 0 (Receptors, N-Acetylglucosamine)
RN  - 0 (TAA90K protein, human)
RN  - 0 (wisteria lectin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Neoplasm/*blood
MH  - Biomarkers/blood
MH  - Echocardiography
MH  - Female
MH  - Glycosylation
MH  - Heart Failure/*blood/diagnosis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Membrane Glycoproteins/*blood
MH  - Middle Aged
MH  - Pilot Projects
MH  - Plant Lectins/*blood
MH  - Receptors, N-Acetylglucosamine/*blood
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Fibrosis
OT  - Heart failure
OT  - Liver function
OT  - Mac-2 Binding Protein Glycosylation Isomer (M2BPGi)
OT  - Wisteria floribunda agglutinin positive Mac-2 binding protein
EDAT- 2017/11/04 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/11/04 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2017/10/20 00:00 [accepted]
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/11/04 06:00 [entrez]
AID - 10.1007/s00380-017-1071-7 [pii]
AID - 10.1007/s00380-017-1071-7 [doi]
PST - ppublish
SO  - Heart Vessels. 2018 Apr;33(4):385-392. doi: 10.1007/s00380-017-1071-7. Epub 2017 
      Nov 2.