PMID- 29098530
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20181113
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 43
IP  - 2
DP  - 2018 Feb
TI  - Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and 
      Cognitive Deficits by Rescuing PI3K/Akt/GSK-3beta Pathway.
PG  - 316-323
LID - 10.1007/s11064-017-2426-2 [doi]
AB  - Clinical studies have demonstrated that decreased adiponectin is associated with 
      the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). 
      We focused on determining the neuroprotective effect offered by adiponectin 
      against streptozotocin-induced brain damage in ICV-STZ rat model. We found that 
      adiponectin supplements significantly restored the cognitive deficits in ICV-STZ 
      rat model including shorter escape latency, more crossing times and increased 
      time spent in the target quadrant. Adiponectin supplements also increased number 
      of dendritic branches and mushroom percentage. In addition, adiponectin 
      supplements attenuated tau hyperphosphorylation at multiple AD-related sites 
      through activation of protein Ser9-phosphorylated glycogen synthase kinase-3beta 
      (Ser9-GSK-3beta) with increased the Akt and PI3K activity. Our data suggest that 
      adiponectin supplements have neuroprotective effects on the ICV-STZ rat model, 
      which may be mediated by the activation of the PI3K/Akt/GSK-3beta signaling pathway.
FAU - Xu, Zhi-Peng
AU  - Xu ZP
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, 
      China.
AD  - Department of Anesthesiology, Wuhan General Hospital of PLA, Wuhan, 430070, 
      China.
FAU - Gan, Guo-Sheng
AU  - Gan GS
AD  - Department of Anesthesiology, Wuhan General Hospital of PLA, Wuhan, 430070, 
      China.
FAU - Liu, Yu-Min
AU  - Liu YM
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, 
      China.
FAU - Xiao, Jin-Song
AU  - Xiao JS
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, 
      China.
FAU - Liu, Han-Xing
AU  - Liu HX
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, 
      China.
FAU - Mei, Bin
AU  - Mei B
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, 
      China.
FAU - Zhang, Jun-Jian
AU  - Zhang JJ
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, 
      China. wdsjkx@163.com.
LA  - eng
GR  - 2014CFB223/Natural Science Foundation of Hubei Province of China/
PT  - Journal Article
DEP - 20171102
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Adiponectin)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (tau Proteins)
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Adiponectin/*pharmacology
MH  - Animals
MH  - Cognition Disorders/drug therapy
MH  - Glycogen Synthase Kinase 3 beta/*drug effects/metabolism
MH  - Male
MH  - Neurons/drug effects/metabolism
MH  - Neuroprotective Agents/pharmacology
MH  - Phosphatidylinositol 3-Kinases/drug effects/metabolism
MH  - Phosphorylation/drug effects
MH  - Proto-Oncogene Proteins c-akt/drug effects/metabolism
MH  - Rats, Sprague-Dawley
MH  - Streptozocin/*pharmacology
MH  - tau Proteins/metabolism/*pharmacology
OTO - NOTNLM
OT  - Adiponectin
OT  - Alzheimer's disease
OT  - Glycogen synthase kinase-3beta
EDAT- 2017/11/04 06:00
MHDA- 2018/08/17 06:00
CRDT- 2017/11/04 06:00
PHST- 2017/06/28 00:00 [received]
PHST- 2017/10/21 00:00 [accepted]
PHST- 2017/09/30 00:00 [revised]
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2017/11/04 06:00 [entrez]
AID - 10.1007/s11064-017-2426-2 [pii]
AID - 10.1007/s11064-017-2426-2 [doi]
PST - ppublish
SO  - Neurochem Res. 2018 Feb;43(2):316-323. doi: 10.1007/s11064-017-2426-2. Epub 2017 
      Nov 2.