PMID- 29098933
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20181113
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 46
IP  - 3
DP  - 2018 Mar
TI  - Association between monocyte chemoattractant protein-1 and blood pressure in 
      smokers.
PG  - 965-974
LID - 10.1177/0300060517723415 [doi]
AB  - Objective The expression level of monocyte chemoattractant protein-1 (MCP-1) is 
      increased in atherosclerotic regions, inducing monocyte migration to the blood 
      vessel wall. Although the serum MCP-1 concentration is higher in patients with 
      than without cardiovascular disease, the precise correlations between the serum 
      MCP-1 concentration and factors associated with smoking and atherosclerosis are 
      unknown. Methods The serum MCP-1 concentration was measured using an 
      enzyme-linked immunosorbent assay in 207 consecutive smokers who visited our 
      smoking cessation clinic. Results Sex-adjusted analysis of smokers revealed that 
      the MCP-1 concentration was positively correlated with age ( beta = 0.311), smoking 
      duration ( beta = 0.342), systolic blood pressure ( beta = 0.225), and diastolic blood 
      pressure ( beta = 0.137) but not with the body mass index. Multivariate regression 
      analysis showed that smoking duration and systolic blood pressure were 
      independent determinants of the MCP-1 concentration. Conclusions The MCP-1 
      concentration was positively correlated with blood pressure among smokers. 
      Long-term smokers with high blood pressure may be more susceptible to plaque 
      rupture at atherosclerotic lesion sites.
FAU - Komiyama, Maki
AU  - Komiyama M
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Takanabe, Rieko
AU  - Takanabe R
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Ono, Koh
AU  - Ono K
AD  - 2 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Shimada, Sayaka
AU  - Shimada S
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Wada, Hiromichi
AU  - Wada H
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Yamakage, Hajime
AU  - Yamakage H
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Satoh-Asahara, Noriko
AU  - Satoh-Asahara N
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Morimoto, Tatsuya
AU  - Morimoto T
AD  - 3 Division of Molecular Medicine, School of Pharmaceutical Sciences, University 
      of Shizuoka, Shizuoka, Japan.
FAU - Shimatsu, Akira
AU  - Shimatsu A
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Takahashi, Yuko
AU  - Takahashi Y
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
FAU - Hasegawa, Koji
AU  - Hasegawa K
AD  - 1 Clinical Research Institute, National Hospital Organization Kyoto Medical 
      Center, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171103
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - *Blood Pressure
MH  - Blood Pressure Determination
MH  - Body Mass Index
MH  - Chemokine CCL2/*blood
MH  - Cigarette Smoking/*blood/physiopathology
MH  - Female
MH  - Humans
MH  - Hypertension/blood/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Smoking Cessation
PMC - PMC5972233
OTO - NOTNLM
OT  - MCP-1
OT  - Smoking
OT  - atherosclerosis
OT  - blood pressure
OT  - cytokine
OT  - inflammation
OT  - obesity
EDAT- 2017/11/04 06:00
MHDA- 2018/08/31 06:00
PMCR- 2018/03/01
CRDT- 2017/11/04 06:00
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
PHST- 2017/11/04 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 10.1177_0300060517723415 [pii]
AID - 10.1177/0300060517723415 [doi]
PST - ppublish
SO  - J Int Med Res. 2018 Mar;46(3):965-974. doi: 10.1177/0300060517723415. Epub 2017 
      Nov 3.