PMID- 29098994
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 0970-2113 (Print)
IS  - 0974-598X (Electronic)
IS  - 0970-2113 (Linking)
VI  - 34
IP  - 6
DP  - 2017 Nov-Dec
TI  - Correlation of cutaneous sensitivity and cytokine response in children with 
      asthma.
PG  - 506-510
LID - 10.4103/lungindia.lungindia_357_16 [doi]
AB  - BACKGROUND: Food allergy occurs in a significant portion of pediatric asthma. 
      Various cells and their mediators/cytokines play a pivotal role in orchestrating 
      the airway inflammatory response in asthma. OBJECTIVE: To study the cutaneous 
      hypersensitivity, Th1, Th2, and Th17 response of pediatric population with asthma 
      and genetic predisposition to atopy, by determining total immunoglobulin E (IgE) 
      level in response to various food allergens. MATERIALS AND METHODS: Fifty 
      asthmatic children with a history of worsening symptoms by various food allergens 
      (study group) and twenty healthy children (control group) were included. Food 
      allergy was assessed through skin prick test (SPT) of various food allergens. 
      Total serum IgE level was measured by sandwich ELISA, and T-cell (Th1, Th2, and 
      Th17)-dependent cytokines were measured by flow cytometry. RESULTS: All 50 
      asthmatic children in the study group showed SPT positivity against various food 
      allergens (rice = 17; banana, fish and groundnut = 10; wheat = 9; milk and orange 
      = 7; egg = 6; and mango = 4). The average total IgE level in the study group was 
      316.8 +/- 189.8 IU/mL. A significant positive correlation of total IgE with 
      interleukin 17 (IL-17) (r = 0.796; P < 0.0001), IL-13 (r = 0.383; P = 0.01), and 
      IL-4 (r = 0.263; P = 0.043) level was noted. A significant negative correlation 
      of total IgE was noted with interferon gamma (r = -0.5823; P < 0.0001) and IL-10 
      (r = -0.4474; P < 0.001) level and the duration of breastfeeding (r = -0.31, P = 
      0.03). CONCLUSIONS: The present study found a positive correlation between total 
      serum IgE level and Th2, Th17 cytokines in a pediatric population with asthma. A 
      significant negative correlation was found between the duration of breastfeeding 
      and the cytokines.
FAU - Singh, Meenu
AU  - Singh M
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Agarwal, Amit
AU  - Agarwal A
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Chatterjee, Bishnupada
AU  - Chatterjee B
AD  - Department of Natural Science, West Bengal University of Technology, Kolkata, 
      West Bengal, India.
FAU - Chauhan, Anil
AU  - Chauhan A
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Das, Rashmi Ranjan
AU  - Das RR
AD  - Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, 
      Odisha, India.
FAU - Paul, Nandini
AU  - Paul N
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Lung India
JT  - Lung India : official organ of Indian Chest Society
JID - 8405380
PMC - PMC5684806
COIS- There are no conflicts of interest.
EDAT- 2017/11/04 06:00
MHDA- 2017/11/04 06:01
PMCR- 2017/11/01
CRDT- 2017/11/04 06:00
PHST- 2017/11/04 06:00 [entrez]
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2017/11/04 06:01 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - LungIndia_2017_34_6_506_217576 [pii]
AID - LI-34-506 [pii]
AID - 10.4103/lungindia.lungindia_357_16 [doi]
PST - ppublish
SO  - Lung India. 2017 Nov-Dec;34(6):506-510. doi: 10.4103/lungindia.lungindia_357_16.