PMID- 29099018
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2076-3271 (Electronic)
IS  - 2076-3271 (Linking)
VI  - 5
IP  - 1
DP  - 2017 Jan 6
TI  - HLA Typing and Celiac Disease in Moroccans.
LID - 10.3390/medsci5010002 [doi]
LID - 2
AB  - Genetic and environmental factors are responsible for differences in the 
      prevalence of some diseases across countries. Human leukocyte antigen (HLA) 
      allele frequencies in North African populations show some differences in their 
      distribution compared to Europeans, Mediterraneans, and sub-Saharans, and some 
      specific alleles and haplotypes could be clinically relevant. Celiac disease (CD) 
      has been fast increasing in prevalence in North Africa; but few immunogenetic 
      data are available for this area, in which a high prevalence of the disease has 
      been described. In this report, we assess and discuss results of HLA class II 
      (HLA-DQA1/DQB1/DRB1) typing in Moroccan patients with CD and compare them with a 
      control population from Morocco-genetically well characterized-and with other 
      North African, Mediterranean, and European populations. The classical HLA-DQ 
      associations were confirmed in Moroccans with CD. The high frequency of DQ2.5 
      homozygosity (45.2%) found in Moroccans with CD was noteworthy as compared with 
      other populations (23%-32%). The genetic risk gradient for CD, identified by 
      previous studies, has been confirmed in Moroccans with some differences, mainly 
      concerning DQ8 genotypes. This study provides the immunogenetic framework of CD 
      in Moroccans and confirms the need to learn more about associations with 
      additional HLA and non-HLA genetic factors.
FAU - Piancatelli, Daniela
AU  - Piancatelli D
AUID- ORCID: 0000-0002-8518-1378
AD  - National Research Council (CNR)-Institute of Translational Pharmacology, U.O.S. 
      L'Aquila, Via Carducci 32, 67100 L'Aquila, Italy. daniela.piancatelli@cnr.it.
FAU - Ben El Barhdadi, Imane
AU  - Ben El Barhdadi I
AD  - Mohammed V-Souissi University, 10000 Rabat, Morocco. ouhabiimane@yahoo.fr.
AD  - Medicine C, Department of Gastroenterology, Ibn Sina Hospital, 10000 Rabat, 
      Morocco. ouhabiimane@yahoo.fr.
FAU - Oumhani, Khadija
AU  - Oumhani K
AD  - Institute National d'Hygiene, 10000 Rabat, Morocco. khaoumhani@gmail.com.
FAU - Sebastiani, Pierluigi
AU  - Sebastiani P
AD  - National Research Council (CNR)-Institute of Translational Pharmacology, U.O.S. 
      L'Aquila, Via Carducci 32, 67100 L'Aquila, Italy. pierluigi.sebastiani@cnr.it.
FAU - Colanardi, Alessia
AU  - Colanardi A
AD  - National Research Council (CNR)-Institute of Translational Pharmacology, U.O.S. 
      L'Aquila, Via Carducci 32, 67100 L'Aquila, Italy. alessia.colanardi@cnr.it.
FAU - Essaid, Abdellah
AU  - Essaid A
AD  - Mohammed V-Souissi University, 10000 Rabat, Morocco. feydi2001@yahoo.fr.
LA  - eng
PT  - Journal Article
DEP - 20170106
PL  - Switzerland
TA  - Med Sci (Basel)
JT  - Medical sciences (Basel, Switzerland)
JID - 101629322
PMC - PMC5635774
OTO - NOTNLM
OT  - HLA
OT  - Morocco
OT  - North Africa
OT  - celiac disease
OT  - population
COIS- The authors declare no conflict of interest.
EDAT- 2017/11/04 06:00
MHDA- 2017/11/04 06:01
PMCR- 2017/01/06
CRDT- 2017/11/04 06:00
PHST- 2016/09/30 00:00 [received]
PHST- 2016/12/07 00:00 [revised]
PHST- 2016/12/22 00:00 [accepted]
PHST- 2017/11/04 06:00 [entrez]
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2017/11/04 06:01 [medline]
PHST- 2017/01/06 00:00 [pmc-release]
AID - medsci5010002 [pii]
AID - medsci-05-00002 [pii]
AID - 10.3390/medsci5010002 [doi]
PST - epublish
SO  - Med Sci (Basel). 2017 Jan 6;5(1):2. doi: 10.3390/medsci5010002.