PMID- 29099059 OWN - NLM STAT- MEDLINE DCOM- 20180619 LR - 20220409 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 18 IP - 11 DP - 2017 Nov 2 TI - Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis. LID - 10.3390/ijms18112312 [doi] LID - 2312 AB - Altered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NSCs/NPCs). Especially, brain-derived neurotrophic factor (BDNF) has been extensively investigated because of its roles in the differentiation/maturation of NSCs/NPCs. On the other hand, recent evidence indicates a negative impact of the stress hormone glucocorticoids (GCs) on the cell fate of NSCs/NPCs, which is also related to the pathophysiology of brain diseases, such as depression and autism spectrum disorder. Furthermore, studies including ours have demonstrated functional interactions between neurotrophic factors and GCs in neural events, including neurogenesis. In this review, we show and discuss relationships among the behaviors of NSCs/NPCs, BDNF, and GCs. FAU - Numakawa, Tadahiro AU - Numakawa T AD - Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-8555, Japan. numakawa.yyrmk@gmail.com. AD - Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo 187-8551, Japan. numakawa.yyrmk@gmail.com. FAU - Odaka, Haruki AU - Odaka H AD - Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-8555, Japan. harukiodaka@ruri.waseda.jp. AD - Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8050, Japan. harukiodaka@ruri.waseda.jp. FAU - Adachi, Naoki AU - Adachi N AD - Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda City, Hyogo 662-8501, Japan. adachi@kwansei.ac.jp. LA - eng PT - Journal Article PT - Review DEP - 20171102 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Glucocorticoids) SB - IM MH - Adult Stem Cells/cytology/metabolism/pathology MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Glucocorticoids/*metabolism MH - Humans MH - Neural Stem Cells/*cytology/metabolism/pathology MH - Neurodegenerative Diseases/metabolism/pathology MH - *Neurogenesis MH - Protein Transport MH - *Stress, Physiological PMC - PMC5713281 OTO - NOTNLM OT - BDNF OT - glucocorticoids OT - intracellular signaling OT - neural stem cells OT - neurogenesis COIS- The authors declare no con fl ict of interest EDAT- 2017/11/04 06:00 MHDA- 2018/06/21 06:00 PMCR- 2017/11/01 CRDT- 2017/11/04 06:00 PHST- 2017/10/06 00:00 [received] PHST- 2017/10/30 00:00 [revised] PHST- 2017/10/31 00:00 [accepted] PHST- 2017/11/04 06:00 [entrez] PHST- 2017/11/04 06:00 [pubmed] PHST- 2018/06/21 06:00 [medline] PHST- 2017/11/01 00:00 [pmc-release] AID - ijms18112312 [pii] AID - ijms-18-02312 [pii] AID - 10.3390/ijms18112312 [doi] PST - epublish SO - Int J Mol Sci. 2017 Nov 2;18(11):2312. doi: 10.3390/ijms18112312.