PMID- 29099859
OWN - NLM
STAT- MEDLINE
DCOM- 20171229
LR  - 20220328
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 11
DP  - 2017
TI  - Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- and 
      depression-like behaviors and memory impairment in restraint stressed rats.
PG  - e0187671
LID - 10.1371/journal.pone.0187671 [doi]
LID - e0187671
AB  - Several severe stressful situations, e.g., natural disaster, infectious disease 
      out break, and mass casualty, are known to cause anxiety, depression and 
      cognitive impairment, and preventive intervention for these stress complications 
      is worth exploring. We have previously reported that the 
      serotonin-norepinephrine-dopamine reuptake inhibitor, venlafaxine, as well as 
      voluntary wheel running are effective in the treatment of anxiety- and 
      depression-like behaviors in stressed rats. But whether they are able to prevent 
      deleterious consequences of restraint stress in rats, such as 
      anxiety/depression-like behaviors and memory impairment that occur afterward, was 
      not known. Herein, male Wistar rats were pre-treated for 4 weeks with 
      anti-anxiety/anti-depressive drugs, agomelatine and venlafaxine, or voluntary 
      wheel running, followed by 4 weeks of restraint-induced stress. During the stress 
      period, rats received neither drug nor exercise intervention. Our results showed 
      that restraint stress induced mixed anxiety- and depression-like behaviors, and 
      memory impairment as determined by elevated plus-maze, elevated T-maze, open 
      field test (OFT), forced swimming test (FST), and Morris water maze (MWM). Both 
      pharmacological pre-treatments and running successfully prevented the 
      anxiety-like behavior, especially learned fear, in stressed rats. MWM test 
      suggested that agomelatine, venlafaxine, and running could prevent stress-induced 
      memory impairment, but only pharmacological treatments led to better novel object 
      recognition behavior and positive outcome in FST. Moreover, western blot analysis 
      demonstrated that venlafaxine and running exercise upregulated brain-derived 
      neurotrophic factor (BDNF) expression in the hippocampus. In conclusion, 
      agomelatine, venlafaxine as well as voluntary wheel running had beneficial 
      effects, i.e., preventing the restraint stress-induced anxiety/depression-like 
      behaviors and memory impairment.
FAU - Lapmanee, Sarawut
AU  - Lapmanee S
AD  - Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 
      Thailand.
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
FAU - Charoenphandhu, Jantarima
AU  - Charoenphandhu J
AUID- ORCID: 0000-0002-7928-7774
AD  - Physiology Division, Preclinical Sciences, Faculty of Medicine, Thammasat 
      University, Pathumthani, Thailand.
FAU - Teerapornpuntakit, Jarinthorn
AU  - Teerapornpuntakit J
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
AD  - Department of Physiology, Faculty of Medical Science, Naresuan University, 
      Phitsanulok, Thailand.
FAU - Krishnamra, Nateetip
AU  - Krishnamra N
AD  - Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 
      Thailand.
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
FAU - Charoenphandhu, Narattaphol
AU  - Charoenphandhu N
AD  - Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 
      Thailand.
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
AD  - Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20171103
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Acetamides)
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 137R1N49AD (agomelatine)
RN  - 7D7RX5A8MO (Venlafaxine Hydrochloride)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Acetamides/*pharmacology
MH  - Animals
MH  - Antidepressive Agents, Second-Generation/*pharmacology
MH  - Body Weight/drug effects
MH  - Corticosterone/blood/urine
MH  - Depression/*prevention & control
MH  - Feeding Behavior/drug effects
MH  - *Immobilization
MH  - Male
MH  - Memory Disorders/*prevention & control
MH  - Organ Size/drug effects
MH  - Physical Conditioning, Animal/*psychology
MH  - Rats
MH  - Rats, Wistar
MH  - Running/*psychology
MH  - *Stress, Physiological
MH  - Venlafaxine Hydrochloride/*pharmacology
PMC - PMC5669450
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/11/04 06:00
MHDA- 2017/12/30 06:00
PMCR- 2017/11/03
CRDT- 2017/11/04 06:00
PHST- 2017/07/05 00:00 [received]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2017/11/04 06:00 [entrez]
PHST- 2017/11/04 06:00 [pubmed]
PHST- 2017/12/30 06:00 [medline]
PHST- 2017/11/03 00:00 [pmc-release]
AID - PONE-D-17-25282 [pii]
AID - 10.1371/journal.pone.0187671 [doi]
PST - epublish
SO  - PLoS One. 2017 Nov 3;12(11):e0187671. doi: 10.1371/journal.pone.0187671. 
      eCollection 2017.