PMID- 29100364
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 44
DP  - 2017 Sep 29
TI  - TCF7L2 rs290481 T>C polymorphism is associated with an increased risk of type 2 
      diabetes mellitus and fasting plasma glucose level.
PG  - 77000-77008
LID - 10.18632/oncotarget.20300 [doi]
AB  - Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene may be 
      key agents in the etiology of type 2 diabetes mellitus (T2DM). In the present 
      case-control study, we aimed to assess the possible relationship of TCF7L2 
      polymorphisms with T2DM and determine the effect of TCF7L2 polymorphisms on the 
      level of fasting plasma glucose (FPG) in Eastern Chinese Han subjects. The TCF7L2 
      rs7903146C>T and rs290481 T>C polymorphisms were genotyped by SNPscan genotyping 
      assays in 502 subjects with T2DM and 782 non-diabetic controls. After adjusting 
      for age, gender, drinking, smoking and body mass index (BMI), the association of 
      TCF7L2 rs7903146C>T and rs290481 T>C polymorphisms with T2DM was determined. We 
      found that TCF7L2 rs290481 T>C polymorphism increased the susceptibility of T2DM 
      in the overall comparison. In subgroup analyses by age, sex, BMI, alcohol use and 
      smoking status, a significantly increased risk of T2DM was also found in female, 
      older subject and never drinking and BMI < 24 kg/m(2) subgroups. The relationship 
      of TCF7L2 rs290481 T>C polymorphism with the biochemistry characteristics in 
      controls was also assessed. We found that TCF7L2 rs290481 T>C polymorphism 
      significantly increased the level of FPG in controls. Our findings suggest that 
      TCF7L2 rs290481 T>C polymorphism is associated with T2DM in Eastern Chinese Han 
      population and links to variations in FPG level. In addition, these relationships 
      are more pronounced in female, older subject and never drinking and BMI < 24 
      kg/m(2) subgroups. A comprehensive fine-mapping study with functional 
      investigation is needed to confirm or refute these potential correlations.
FAU - Zhu, Li
AU  - Zhu L
AD  - Department of Nephrology, Affiliated People's Hospital of Jiangsu University, 
      Zhenjiang, Jiangsu Province, China.
FAU - Xie, Zhiqiang
AU  - Xie Z
AD  - Department of Clinical Laboratory, Fujian Medical University Union Hospital, 
      Fuzhou, Fujian Province, China.
FAU - Lu, Jianping
AU  - Lu J
AD  - Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer 
      Hospital, Fuzhou, Fujian Province, China.
FAU - Hao, Qiu
AU  - Hao Q
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu Province, China.
FAU - Kang, Mingqiang
AU  - Kang M
AD  - Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, 
      Fujian Province, China.
FAU - Chen, Shuchen
AU  - Chen S
AD  - Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, 
      Fujian Province, China.
FAU - Tang, Weifeng
AU  - Tang W
AD  - Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, 
      Fujian Province, China.
FAU - Ding, Hao
AU  - Ding H
AD  - Department of Respiratory Disease, Affiliated People's Hospital of Jiangsu 
      University, Zhenjiang, Jiangsu Province, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical 
      University Cancer Hospital, Fuzhou, Fujian Province, China.
FAU - Liu, Chao
AU  - Liu C
AD  - Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu 
      University, Zhenjiang, Jiangsu Province, China.
FAU - Wu, Haojie
AU  - Wu H
AD  - Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen, Fujian 
      Province, China.
LA  - eng
PT  - Journal Article
DEP - 20170816
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5652758
OTO - NOTNLM
OT  - TCF7L2
OT  - polymorphism
OT  - risk
OT  - type 2 diabetes mellitus
COIS- CONFLICTS OF INTERESTS The authors have no potential financial conflicts of 
      interests.
EDAT- 2017/11/05 06:00
MHDA- 2017/11/05 06:01
PMCR- 2017/09/29
CRDT- 2017/11/05 06:00
PHST- 2017/04/19 00:00 [received]
PHST- 2017/06/20 00:00 [accepted]
PHST- 2017/11/05 06:00 [entrez]
PHST- 2017/11/05 06:00 [pubmed]
PHST- 2017/11/05 06:01 [medline]
PHST- 2017/09/29 00:00 [pmc-release]
AID - 20300 [pii]
AID - 10.18632/oncotarget.20300 [doi]
PST - epublish
SO  - Oncotarget. 2017 Aug 16;8(44):77000-77008. doi: 10.18632/oncotarget.20300. 
      eCollection 2017 Sep 29.