PMID- 29100428
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 44
DP  - 2017 Sep 29
TI  - Lactate stimulates CA IX expression in normoxic cancer cells.
PG  - 77819-77835
LID - 10.18632/oncotarget.20836 [doi]
AB  - Besides hypoxia, other factors and molecules such as lactate, succinate, and 
      reactive oxygen species activate transcription factor hypoxia-inducible factor-1 
      (HIF-1) even in normoxia. One of the main target gene products of HIF-1 is 
      carbonic anhydrase IX (CA IX). CA IX is overexpressed in many tumors and serves 
      as prognostic factor for hypoxic, aggressive and malignant cancers. CA IX is also 
      induced in normoxia in high cell density. In this study, we observed that lactate 
      induces CA IX expression in normoxic cancer cells in vitro and in vivo. We 
      further evidenced that participation of both HIF-1 and specificity protein 1 
      (SP1) transcription factors is crucial for lactate-driven normoxic induction of 
      the CA9 gene. By inducing CA IX, lactate can facilitate the maintenance of cancer 
      cell aggressive behavior in normoxia.
FAU - Panisova, Elena
AU  - Panisova E
AD  - Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
FAU - Kery, Martin
AU  - Kery M
AD  - Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
FAU - Sedlakova, Olga
AU  - Sedlakova O
AD  - Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
FAU - Brisson, Lucie
AU  - Brisson L
AD  - Unit of Pharmacology and Therapeutics, Institut de Recherche Experimentale et 
      Clinique (IREC), Universite Catholique de Louvain (UCL), Brussels, Belgium.
AD  - Inserm UMR1069, Nutrition, Croissance et Cancer, Universite Francois-Rabelais, 
      Tours, France.
FAU - Debreova, Michaela
AU  - Debreova M
AD  - Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
FAU - Sboarina, Martina
AU  - Sboarina M
AD  - Unit of Pharmacology and Therapeutics, Institut de Recherche Experimentale et 
      Clinique (IREC), Universite Catholique de Louvain (UCL), Brussels, Belgium.
FAU - Sonveaux, Pierre
AU  - Sonveaux P
AD  - Unit of Pharmacology and Therapeutics, Institut de Recherche Experimentale et 
      Clinique (IREC), Universite Catholique de Louvain (UCL), Brussels, Belgium.
FAU - Pastorekova, Silvia
AU  - Pastorekova S
AD  - Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
FAU - Svastova, Eliska
AU  - Svastova E
AD  - Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
LA  - eng
PT  - Journal Article
DEP - 20170912
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5652817
OTO - NOTNLM
OT  - HIF-1
OT  - MCT1
OT  - carbonic anhydrase IX
OT  - lactate
OT  - tumor metabolism
COIS- CONFLICTS OF INTEREST The authors have declared that no conflicts of interest 
      exists.
EDAT- 2017/11/05 06:00
MHDA- 2017/11/05 06:01
PMCR- 2017/09/29
CRDT- 2017/11/05 06:00
PHST- 2017/02/28 00:00 [received]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/11/05 06:00 [entrez]
PHST- 2017/11/05 06:00 [pubmed]
PHST- 2017/11/05 06:01 [medline]
PHST- 2017/09/29 00:00 [pmc-release]
AID - 20836 [pii]
AID - 10.18632/oncotarget.20836 [doi]
PST - epublish
SO  - Oncotarget. 2017 Sep 12;8(44):77819-77835. doi: 10.18632/oncotarget.20836. 
      eCollection 2017 Sep 29.