PMID- 29100915 OWN - NLM STAT- MEDLINE DCOM- 20190315 LR - 20221207 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 12 IP - 1 DP - 2018 Jan-Feb TI - Dynamic status of metabolically healthy overweight/obesity and metabolically unhealthy and normal weight and the risk of type 2 diabetes mellitus: A cohort study of a rural adult Chinese population. PG - 61-71 LID - S1871-403X(17)30117-5 [pii] LID - 10.1016/j.orcp.2017.10.005 [doi] AB - OBJECTIVE: We aimed to determine dynamic status of metabolically healthy overweight or obesity (MHO) and metabolically unhealthy and normal weight (MUNW) and the risk of incident type 2 diabetes mellitus (T2DM). METHODS: Body mass index and metabolic health were assessed on 11,865 eligible participants >/=18 years from 6-year follow-up cohort study of a rural Chinese population. Participants were classified as metabolically healthy and normal weight (MHNW), MHO, MUNW and metabolically unhealthy overweight or obesity (MUO) at both baseline and follow-up examinations. Hazard ratio (HR) and 95% confidence interval (CI) were used to assess baseline and their changes of BMI-metabolic status and the risk of incident T2DM. RESULTS: Risk of T2DM was increased for all participants with baseline MHO, MUNW, and MUO (adjusted HR 1.94, 95% CI 1.33-2.81; 3.10, 95% CI 2.19-4.39; and 6.63, 95% CI 4.94-8.90, all P<0.001, respectively). However, risk of T2DM was increased for participants with transformation from MHO to MUO (4.52, 95% CI 2.42-8.47, P<0.001) as compared with stable MHNW, but not stable MHO (0.53, 95CI 0.20-1.40, P=0.20). Risk of T2DM did not differ between participants with transformation from MUNW to metabolically healthy and those with stable MHNW (P>0.05), but was increased with stable MUNW (5.78, 95% CI 3.15-10.62, P<0.001). The results were consistent when analyses were restricted to participants without baseline impaired fasting glucose level. CONCLUSIONS: Our findings provide understanding for differentiating high-risk individuals for incident T2DM in Chinese population. CI - Copyright (c) 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. FAU - Wang, Bingyuan AU - Wang B AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Ming AU - Zhang M AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Wang, Shu AU - Wang S AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Wang, Chongjian AU - Wang C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Wang, Jinjin AU - Wang J AD - Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, People's Republic of China. FAU - Li, Linlin AU - Li L AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Lu AU - Zhang L AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Ren, Yongcheng AU - Ren Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China; Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China; The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Han, Chengyi AU - Han C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China; Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China; The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China; Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China; The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Zhou, Junmei AU - Zhou J AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China; The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Wang, Guo'an AU - Wang G AD - Department of Pharmacy, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Shen, Yanxia AU - Shen Y AD - Department of Clinical Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Wu, Dongting AU - Wu D AD - Department of Clinical Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Pang, Chao AU - Pang C AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Yin, Lei AU - Yin L AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Feng, Tianping AU - Feng T AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Zhao, Jingzhi AU - Zhao J AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Luo, Xinping AU - Luo X AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Hu, Dongsheng AU - Hu D AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address: hud@szu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20171031 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 SB - IM MH - Adult MH - Asian People/*statistics & numerical data MH - Body Mass Index MH - China/epidemiology MH - Cluster Analysis MH - Diabetes Mellitus, Type 2/*epidemiology/physiopathology MH - Follow-Up Studies MH - Humans MH - Ideal Body Weight MH - Male MH - Middle Aged MH - Obesity/*epidemiology/physiopathology MH - Obesity, Metabolically Benign/*epidemiology/physiopathology MH - Risk Factors MH - Rural Population/*statistics & numerical data OTO - NOTNLM OT - Cohort study OT - Diabetes mellitus OT - Epidemiology OT - Metabolic diseases OT - Obesity EDAT- 2017/11/05 06:00 MHDA- 2019/03/16 06:00 CRDT- 2017/11/05 06:00 PHST- 2017/06/07 00:00 [received] PHST- 2017/09/16 00:00 [revised] PHST- 2017/10/10 00:00 [accepted] PHST- 2017/11/05 06:00 [pubmed] PHST- 2019/03/16 06:00 [medline] PHST- 2017/11/05 06:00 [entrez] AID - S1871-403X(17)30117-5 [pii] AID - 10.1016/j.orcp.2017.10.005 [doi] PST - ppublish SO - Obes Res Clin Pract. 2018 Jan-Feb;12(1):61-71. doi: 10.1016/j.orcp.2017.10.005. Epub 2017 Oct 31.