PMID- 29100942
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20180717
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 79
IP  - 1
DP  - 2018 Jan
TI  - Association between KIR genes and dust mite sensitization in a Brazilian 
      population.
PG  - 51-56
LID - S0198-8859(17)30527-X [pii]
LID - 10.1016/j.humimm.2017.10.018 [doi]
AB  - BACKGROUND: Killer cell immunoglobulin-like receptors (KIRs), found on the 
      surface of natural killer (NK) cells, play a key role in controlling the innate 
      response. Such response depends on a series of cellular interactions between 
      these receptors and HLA activating/inhibiting ligands. Atopic diseases have been 
      associated with genes that regulate cytokine production and HLA genes, which may 
      either protect or predispose to hypersensitivity. OBJECTIVE: To verify an 
      association study of KIR genes with sensitization to the following mites: 
      Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Blomia tropicalis. 
      METHODS: A total of 341 children aged up to 14 years, were classified as 
      mite-sensitive or mite-insensitive after undergoing a skin prick test for 
      immediate allergic reactions. The presence/absence of KIR genes and their human 
      leukocyte antigen (HLA) ligands was determined by polymerase chain 
      reaction-sequence specific oligonucleotide (PCR-SSO) with the commercial kit 
      LabType using Luminex. RESULTS: The frequencies of KIR genes and their 
      respective class I HLA ligands and the frequency of haplotypes were performed in 
      sensitive and insensitive individuals, and no significant differences were found. 
      CONCLUSION: Our results suggest no influence of KIR genes on 
      resistance/susceptibility to sensitization to dust mites.
CI  - Copyright (c) 2017 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Caniatti, Marcela Caleffi da Costa Lima
AU  - Caniatti MCDCL
AD  - Department of Basic Health Sciences, Universidade Estadual de Maringa (UEM), 
      Maringa, Parana, Brazil. Electronic address: marcela@caniatti.com.br.
FAU - Borelli, Sueli Donizete
AU  - Borelli SD
AD  - Department of Basic Health Sciences, Universidade Estadual de Maringa (UEM), 
      Maringa, Parana, Brazil.
FAU - Guilherme, Ana Lucia Falavigna
AU  - Guilherme ALF
AD  - Department of Basic Health Sciences, Universidade Estadual de Maringa (UEM), 
      Maringa, Parana, Brazil.
FAU - Franzener, Soraya Barrionuevo
AU  - Franzener SB
AD  - Department of Basic Health Sciences, Universidade Estadual de Maringa (UEM), 
      Maringa, Parana, Brazil.
FAU - Tsuneto, Luiza Tamie
AU  - Tsuneto LT
AD  - Department of Basic Health Sciences, Universidade Estadual de Maringa (UEM), 
      Maringa, Parana, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20171031
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Brazil
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Hypersensitivity/diagnosis/*genetics
MH  - Immunity, Innate/genetics
MH  - Immunization
MH  - Killer Cells, Natural/*immunology
MH  - Male
MH  - Polymorphism, Genetic
MH  - Pyroglyphidae
MH  - Receptors, KIR/*genetics
MH  - Skin Tests
OTO - NOTNLM
OT  - Genetic association studies
OT  - Genetic heterogeneity
OT  - HLA antigens
OT  - KIR receptors
OT  - Mites
EDAT- 2017/11/05 06:00
MHDA- 2018/07/18 06:00
CRDT- 2017/11/05 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2017/10/29 00:00 [revised]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/11/05 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/11/05 06:00 [entrez]
AID - S0198-8859(17)30527-X [pii]
AID - 10.1016/j.humimm.2017.10.018 [doi]
PST - ppublish
SO  - Hum Immunol. 2018 Jan;79(1):51-56. doi: 10.1016/j.humimm.2017.10.018. Epub 2017 
      Oct 31.