PMID- 29101742 OWN - NLM STAT- MEDLINE DCOM- 20171116 LR - 20181113 IS - 1608-3091 (Electronic) IS - 1607-6729 (Linking) VI - 476 IP - 1 DP - 2017 Sep TI - A novel dimeric dipeptide mimetic of the BDNF selectively activates the MAPK-Erk signaling pathway. PG - 291-295 LID - 10.1134/S1607672917050027 [doi] AB - On the basis of the structure of beta-turn of loop 2 of brain-derived neurotrophic factor (BDNF), its new dimeric dipeptide mimetic bis-(N-hexanoyl-L-seryl-L-lysine) hexamethylenediamide (GTS-201) was created. It activated TrkB and Erk, did not activate Akt, and exhibited neuroprotective activity in vitro at concentrations of 10(-5)-10(-8) M. Unlike the mimetics that activate Erk and Akt, GTS-201 did not exhibit antidepressant properties. For the manifestation of the antidepressant activity of BDNF mimetics, the activation of its both major signaling pathways is required. FAU - Gudasheva, T A AU - Gudasheva TA AD - Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia. tata-sosnovka@mail.ru. FAU - Tarasiuk, A V AU - Tarasiuk AV AD - Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia. FAU - Sazonova, N M AU - Sazonova NM AD - Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia. FAU - Povarnina, P Yu AU - Povarnina PY AD - Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia. FAU - Antipova, T A AU - Antipova TA AD - Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia. FAU - Seredenin, S B AU - Seredenin SB AD - Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia. LA - eng PT - Journal Article DEP - 20171104 PL - United States TA - Dokl Biochem Biophys JT - Doklady. Biochemistry and biophysics JID - 101126895 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Dipeptides) RN - 0 (Neuroprotective Agents) RN - 0 (Peptidomimetics) RN - EC 2.7.10.1 (Receptor, trkB) RN - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) RN - EC 2.7.11.25 (MAP Kinase Kinase Kinase 5) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*chemistry MH - Cell Line MH - *Dimerization MH - Dipeptides/*chemistry MH - Extracellular Signal-Regulated MAP Kinases/*metabolism MH - MAP Kinase Kinase Kinase 5/*drug effects MH - Mice MH - Neuroprotective Agents/chemistry/pharmacology MH - Peptidomimetics/*chemistry/*pharmacology MH - Receptor, trkB/metabolism EDAT- 2017/11/05 06:00 MHDA- 2017/11/29 06:00 CRDT- 2017/11/05 06:00 PHST- 2017/03/15 00:00 [received] PHST- 2017/11/05 06:00 [entrez] PHST- 2017/11/05 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] AID - 10.1134/S1607672917050027 [pii] AID - 10.1134/S1607672917050027 [doi] PST - ppublish SO - Dokl Biochem Biophys. 2017 Sep;476(1):291-295. doi: 10.1134/S1607672917050027. Epub 2017 Nov 4.