PMID- 29102372 OWN - NLM STAT- MEDLINE DCOM- 20181211 LR - 20220410 IS - 1523-1755 (Electronic) IS - 0085-2538 (Linking) VI - 93 IP - 1 DP - 2018 Jan TI - Renal potassium physiology: integration of the renal response to dietary potassium depletion. PG - 41-53 LID - S0085-2538(17)30625-7 [pii] LID - 10.1016/j.kint.2017.08.018 [doi] AB - We summarize the current understanding of the physiology of the renal handling of potassium (K(+)), and present an integrative view of the renal response to K(+) depletion caused by dietary K(+) restriction. This renal response involves contributions from different nephron segments, and aims to diminish the rate of excretion of K(+) as a result of: decreasing the rate of electrogenic (and increasing the rate of electroneutral) reabsorption of sodium in the aldosterone-sensitive distal nephron (ASDN), decreasing the abundance of renal outer medullary K(+) channels in the luminal membrane of principal cells in the ASDN, decreasing the flow rate in the ASDN, and increasing the reabsorption of K(+) in the cortical and medullary collecting ducts. The implications of this physiology for the association between K(+) depletion and hypertension, and K(+) depletion and formation of calcium kidney stones are discussed. CI - Copyright (c) 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved. FAU - Kamel, Kamel S AU - Kamel KS AD - Renal Division, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address: kamel.kamel@utoronto.ca. FAU - Schreiber, Martin AU - Schreiber M AD - Renal Division, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Halperin, Mitchell L AU - Halperin ML AD - Renal Division, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. LA - eng PT - Journal Article PT - Review PL - United States TA - Kidney Int JT - Kidney international JID - 0323470 RN - 0 (Potassium, Dietary) SB - IM MH - Adaptation, Physiological MH - Animals MH - Humans MH - Hypertension/physiopathology/urine MH - Kidney Calculi/physiopathology/urine MH - Nephrons/*metabolism/physiopathology MH - Potassium Deficiency/physiopathology/*urine MH - Potassium, Dietary/*urine MH - *Renal Elimination MH - *Renal Reabsorption OTO - NOTNLM OT - WNK kinases OT - aldosterone OT - pendrin OT - potassium depletion EDAT- 2017/11/06 06:00 MHDA- 2018/12/12 06:00 CRDT- 2017/11/06 06:00 PHST- 2017/03/10 00:00 [received] PHST- 2017/07/31 00:00 [revised] PHST- 2017/08/03 00:00 [accepted] PHST- 2017/11/06 06:00 [pubmed] PHST- 2018/12/12 06:00 [medline] PHST- 2017/11/06 06:00 [entrez] AID - S0085-2538(17)30625-7 [pii] AID - 10.1016/j.kint.2017.08.018 [doi] PST - ppublish SO - Kidney Int. 2018 Jan;93(1):41-53. doi: 10.1016/j.kint.2017.08.018.