PMID- 29102593
OWN - NLM
STAT- MEDLINE
DCOM- 20180807
LR  - 20210109
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 339
DP  - 2018 Feb 26
TI  - Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of 
      Alzheimer's disease.
PG  - 297-304
LID - S0166-4328(17)31520-6 [pii]
LID - 10.1016/j.bbr.2017.10.032 [doi]
AB  - Mesenchymal stem cell transplantation is a promising therapeutic approach for 
      Alzheimer's disease (AD). However, poor engraftment and limited survival rates 
      are major obstacles for its clinical application. Resveratrol, an activator of 
      silent information regulator 2, homolog 1 (SIRT1), regulates cell destiny and is 
      beneficial for neurodegenerative disorders. The present study is designed to 
      explore whether resveratrol regulates the fate of human umbilical cord-derived 
      mesenchymal stem cells (hUC-MSCs) and whether hUC-MSCs combined with resveratrol 
      would be efficacious in the treatment of neurodegeneration in a mouse model of AD 
      through SIRT1 signaling. Herein, we report that resveratrol facilitates hUC-MSCs 
      engraftment in the hippocampus of AD mice and resveratrol enhances the 
      therapeutic effects of hUC-MSCs in this model as demonstrated by improved 
      learning and memory in the Morris water maze, enhanced neurogenesis and 
      alleviated neural apoptosis in the hippocampus of the AD mice. Moreover, hUC-MSCs 
      and resveratrol jointly regulate expression of hippocampal SIRT1, PCNA, p53, 
      ac-p53, p21, and p16. These data strongly suggests that hUC-MSCs transplantation 
      combined with resveratrol may be an effective therapy for AD.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Wang, Xinxin
AU  - Wang X
AD  - Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China. Electronic address: wangxinxin058@126.com.
FAU - Ma, Shanshan
AU  - Ma S
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan, China. Electronic address: yangbo96@126.com.
FAU - Huang, Tuanjie
AU  - Huang T
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Meng, Nan
AU  - Meng N
AD  - The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
FAU - Xu, Ling
AU  - Xu L
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Xing, Qu
AU  - Xing Q
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Zhang, Yanting
AU  - Zhang Y
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Zhang, Kun
AU  - Zhang K
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Li, Qinghua
AU  - Li Q
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Zhang, Tao
AU  - Zhang T
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
FAU - Wu, Junwei
AU  - Wu J
AD  - The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
FAU - Yang, Greta Luyuan
AU  - Yang GL
AD  - Stuyvesant High School, New York, USA.
FAU - Guan, Fangxia
AU  - Guan F
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; The First 
      Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic 
      address: guanfangxia@126.com.
FAU - Wang, Jian
AU  - Wang J
AD  - Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China; Department 
      of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of 
      Medicine, Baltimore, MD,USA.
LA  - eng
GR  - R01 AT007317/AT/NCCIH NIH HHS/United States
GR  - R01 NS078026/NS/NINDS NIH HHS/United States
GR  - R21 NS101614/NS/NINDS NIH HHS/United States
GR  - R56 NS096549/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20171102
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Alzheimer Disease/metabolism/*therapy
MH  - Animals
MH  - Cell Differentiation/*drug effects
MH  - Disease Models, Animal
MH  - Hippocampus/cytology/drug effects
MH  - Humans
MH  - Memory/drug effects
MH  - *Mesenchymal Stem Cell Transplantation/methods
MH  - Mesenchymal Stem Cells/cytology/*drug effects
MH  - Mice, Transgenic
MH  - Neurogenesis/drug effects/physiology
MH  - Neurons/cytology/drug effects
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
MH  - Umbilical Cord/cytology
PMC - PMC5729114
MID - NIHMS922220
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Human umbilical cord-derived mesenchymal stem cells
OT  - Resveratrol, SIRT1
OT  - Transgenic mice
COIS- Disclosure statement The authors have no competing interests.
EDAT- 2017/11/06 06:00
MHDA- 2018/08/08 06:00
PMCR- 2018/02/26
CRDT- 2017/11/06 06:00
PHST- 2017/09/19 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/11/06 06:00 [pubmed]
PHST- 2018/08/08 06:00 [medline]
PHST- 2017/11/06 06:00 [entrez]
PHST- 2018/02/26 00:00 [pmc-release]
AID - S0166-4328(17)31520-6 [pii]
AID - 10.1016/j.bbr.2017.10.032 [doi]
PST - ppublish
SO  - Behav Brain Res. 2018 Feb 26;339:297-304. doi: 10.1016/j.bbr.2017.10.032. Epub 
      2017 Nov 2.