PMID- 29102768 OWN - NLM STAT- MEDLINE DCOM- 20180518 LR - 20221207 IS - 1778-3585 (Electronic) IS - 0924-9338 (Linking) VI - 46 DP - 2017 Oct TI - Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study. PG - 65-71 LID - S0924-9338(17)32911-5 [pii] LID - 10.1016/j.eurpsy.2017.06.009 [doi] AB - The neurotrophic factors (NTF) hypothesis of depression was postulated nearly a decade ago and is nowadays widely acknowledged. Previous reports suggest that cerebral concentrations of NTF may be reduced in suicide victims who received minimal or no antidepressant pharmacotherapy. Recent evidence suggests that antidepressant treatment may improve or normalise cerebral concentrations of neurotrophic factors. Therefore, we examined the concentration of brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) in different brain regions (cortex, cingulate gyrus, thalamus, hippocampus, putamen and nucleus caudatus) of 21 individuals - 7 patients of which 4 patients with major depressive disorder (MDD) and overall age 86.8+/-5 years who received antidepressant pharmacotherapy (selective serotonin re-uptake inhibitors [SSRI]; tricyclic antidepressants [TCA]), 3 patients with MDD without antidepressant treatment and overall age 84.3+/-5 years versus 14 unaffected subjects at age 70.3+/-13.8. We detected significant elevation of BDNF (parietal cortex) and NT3 (parietal, temporal and occipital cortex, cingulate gyrus, thalamus, putamen and nucleus caudatus regions) in MDD patients who received antidepressant medication compared to MDD untreated patients and controls. Moreover, we detected a significant decrease of NT3 levels in the parietal cortex of patients suffering from MDD non-treated patients without treatment compared to healthy individuals. Although the limited statistical power due to the small sample size in this proof of concept study corroborates data from previous studies, which show that treatment with antidepressants mediates alterations in neuroplasticity via the action of NTF. However, more research using post-mortem brain tissue with larger samples needs to be carried out as well as longitudinal studies to further verify these results. CI - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved. FAU - Sheldrick, A AU - Sheldrick A AD - Department Psychiatry Odense, Psychiatry in the Region of Southern Denmark, J.B. Winslowsvej 20, 5000 Odense C, Denmark. FAU - Camara, S AU - Camara S AD - Clinical Neurochemistry, Department Psychiatry and Psychotherapy, University Hospital Wurzburg, Furchsleinstr. 15, 97080 Wurzburg, Germany. FAU - Ilieva, M AU - Ilieva M AD - Department of Psychiatry, Institute for Clinical Research, University of Southern Denmark, J.B. Winslowsvej 19, 5000 Odense C, Denmark. Electronic address: milieva@health.sdu.dk. FAU - Riederer, P AU - Riederer P AD - Department Psychiatry Odense, Psychiatry in the Region of Southern Denmark, J.B. Winslowsvej 20, 5000 Odense C, Denmark; Clinical Neurochemistry, Department Psychiatry and Psychotherapy, University Hospital Wurzburg, Furchsleinstr. 15, 97080 Wurzburg, Germany; Department of Psychiatry, Institute for Clinical Research, University of Southern Denmark, J.B. Winslowsvej 19, 5000 Odense C, Denmark; Department Neurobiology, Instiute for Molecular Medicine, 5000 Odense C, Denmark; Center for applied Neuroscience, BRIDGE, Odense University Hospital, Psychiatry in the Region of Southern Denmark, University of Southern Denmark, 5000 Odense C, Denmark. FAU - Michel, T M AU - Michel TM AD - Department Psychiatry Odense, Psychiatry in the Region of Southern Denmark, J.B. Winslowsvej 20, 5000 Odense C, Denmark; Department of Psychiatry, Institute for Clinical Research, University of Southern Denmark, J.B. Winslowsvej 19, 5000 Odense C, Denmark; Department Neurobiology, Instiute for Molecular Medicine, 5000 Odense C, Denmark; Center for applied Neuroscience, BRIDGE, Odense University Hospital, Psychiatry in the Region of Southern Denmark, University of Southern Denmark, 5000 Odense C, Denmark. LA - eng PT - Journal Article DEP - 20170711 PL - England TA - Eur Psychiatry JT - European psychiatry : the journal of the Association of European Psychiatrists JID - 9111820 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (NTF3 protein, human) RN - 0 (Nerve Growth Factors) RN - 0 (Neurotrophin 3) RN - 0 (Serotonin Uptake Inhibitors) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Antidepressive Agents/pharmacology/therapeutic use MH - Autopsy MH - Brain/drug effects/*metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Case-Control Studies MH - Depression/drug therapy/*metabolism MH - Depressive Disorder, Major/drug therapy/*metabolism MH - Female MH - Humans MH - Male MH - Middle Aged MH - Nerve Growth Factors/*metabolism MH - Neuronal Plasticity/drug effects MH - Neurotrophin 3/*metabolism MH - *Proof of Concept Study MH - Selective Serotonin Reuptake Inhibitors/pharmacology/therapeutic use MH - Suicide OTO - NOTNLM OT - *Affective disorders OT - *Antidepressants OT - *Depression OT - *Molecular biology OT - *Psychiatry OT - *Psychopharmacology EDAT- 2017/11/06 06:00 MHDA- 2018/05/19 06:00 CRDT- 2017/11/06 06:00 PHST- 2017/04/12 00:00 [received] PHST- 2017/06/14 00:00 [revised] PHST- 2017/06/16 00:00 [accepted] PHST- 2017/11/06 06:00 [pubmed] PHST- 2018/05/19 06:00 [medline] PHST- 2017/11/06 06:00 [entrez] AID - S0924-9338(17)32911-5 [pii] AID - 10.1016/j.eurpsy.2017.06.009 [doi] PST - ppublish SO - Eur Psychiatry. 2017 Oct;46:65-71. doi: 10.1016/j.eurpsy.2017.06.009. Epub 2017 Jul 11.