PMID- 29102837 OWN - NLM STAT- MEDLINE DCOM- 20180823 LR - 20220408 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 227 DP - 2018 Feb TI - BDNF Val66Met polymorphism, life stress and depression: A meta-analysis of gene-environment interaction. PG - 226-235 LID - S0165-0327(17)31126-6 [pii] LID - 10.1016/j.jad.2017.10.024 [doi] AB - BACKGROUND: Depression is thought to be multifactorial in etiology, including genetic and environmental components. While a number of gene-environment interaction studies have been carried out, meta-analyses are scarce. The present meta-analysis aimed to quantify evidence on the interaction between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and stress in depression. METHODS: Included were 31 peer-reviewed with a pooled total of 21060 participants published before October 2016 and literature searches were conducted using PubMed, Wolters Kluwer, Web of Science, EBSCO, Elsevier Science Direct and Baidu Scholar databases. RESULTS: The results indicated that the Met allele of BDNF Val66Met polymorphism significantly moderated the relationship between stress and depression (Z=2.666, p = 0.003). The results of subgroup analysis concluded that stressful life events and childhood adversity separately interacted with the Met allele of BDNF Val66Met polymorphism in depression (Z = 2.552, p = 0.005; Z = 1.775, p = 0.03). LIMITATIONS: The results could be affected by errors or bias in primary studies which had small sample sizes with relatively lower statistic power. We could not estimate how strong the interaction effect between gene and environment was. CONCLUSIONS: We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Zhao, Mingzhe AU - Zhao M AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 1018625419@qq.com. FAU - Chen, Lu AU - Chen L AD - 1# Shuaifuyuan, Dongcheng District, Beijing 100730, China. Electronic address: 738246255@qq.com. FAU - Yang, Jiarun AU - Yang J AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 1287991708@qq.com. FAU - Han, Dong AU - Han D AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 319880222@qq.com. FAU - Fang, Deyu AU - Fang D AD - Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States. Electronic address: fangD@northwestern.edu. FAU - Qiu, Xiaohui AU - Qiu X AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 409020754@qq.com. FAU - Yang, Xiuxian AU - Yang X AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 125020874@qq.com. FAU - Qiao, Zhengxue AU - Qiao Z AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 83571560@qq.com. FAU - Ma, Jingsong AU - Ma J AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 13945105753@126.com. FAU - Wang, Lin AU - Wang L AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 466373279@qq.com. FAU - Jiang, Shixiang AU - Jiang S AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 32871873@qq.com. FAU - Song, Xuejia AU - Song X AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 4874452@qq.com. FAU - Zhou, Jiawei AU - Zhou J AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 546732035@qq.com. FAU - Zhang, Jian AU - Zhang J AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: tengteng198312@126.com. FAU - Chen, Mingqi AU - Chen M AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 366129091@qq.com. FAU - Qi, Dong AU - Qi D AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: 550491055@qq.com. FAU - Yang, Yanjie AU - Yang Y AD - No. 157, Baojian Road, Nangang District, Harbin 150081, China. Electronic address: yanjie1965@163.com. FAU - Pan, Hui AU - Pan H AD - 1# Shuaifuyuan, Dongcheng District, Beijing 100730, China. Electronic address: Panhui20111111@163.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20171016 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Brain-Derived Neurotrophic Factor/*genetics MH - Depression/*genetics MH - *Gene-Environment Interaction MH - *Genetic Predisposition to Disease MH - Humans MH - Polymorphism, Single Nucleotide/genetics MH - Stress, Psychological/*genetics OTO - NOTNLM OT - BDNF OT - Childhood adversity OT - Depression OT - Gene-environment interaction OT - Stressful life events EDAT- 2017/11/06 06:00 MHDA- 2018/08/24 06:00 CRDT- 2017/11/06 06:00 PHST- 2017/06/03 00:00 [received] PHST- 2017/09/25 00:00 [revised] PHST- 2017/10/04 00:00 [accepted] PHST- 2017/11/06 06:00 [pubmed] PHST- 2018/08/24 06:00 [medline] PHST- 2017/11/06 06:00 [entrez] AID - S0165-0327(17)31126-6 [pii] AID - 10.1016/j.jad.2017.10.024 [doi] PST - ppublish SO - J Affect Disord. 2018 Feb;227:226-235. doi: 10.1016/j.jad.2017.10.024. Epub 2017 Oct 16.