PMID- 29103510
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20180830
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 180
DP  - 2018 Jan 15
TI  - Regenerated chitin fibers reinforced with bacterial cellulose nanocrystals as 
      suture biomaterials.
PG  - 304-313
LID - S0144-8617(17)31168-2 [pii]
LID - 10.1016/j.carbpol.2017.10.022 [doi]
AB  - The objective of this work was to prepare a novel filament with good 
      biocompatibility and mechanical performance which can meet the demands of 
      surgical sutures. Bacterial cellulose nanocrystals (BCNCs) were used to reinforce 
      regenerated chitin (RC) fibers to form BCNC/RC filaments. Mechanical performance 
      measurements demonstrated that the strength of the BCNC/RC filament was increased 
      dramatically over the RC analogue. A yarn made of 30 BCNC-loaded fibers also 
      achieved satisfactory mechanical performance, with a knot-pull tensile strength 
      of 9.8+/-0.6N. Enzymatic degradation studies showed the BCNC/RC materials to have 
      good biodegradability, the rate of which can be tuned by varying the 
      concentration of BCNCs in the yarn. The RC and the BCNC/RC materials had no 
      cytotoxicity and can promote cell proliferation. In vivo experiments on mice 
      demonstrated that suturing with the BCNC/RC yarn can promote wound healing 
      without obvious adverse effects.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Wu, Huanling
AU  - Wu H
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, PR China; Jiuzhou College of Pharmacy, Yancheng Vocational 
      Institute of Industry Technology, Yancheng 224005, PR China.
FAU - Williams, Gareth R
AU  - Williams GR
AD  - UCL School of Pharmacy, University College London, 29-39 Brunswick Square, 
      London, WC1N 1AX, UK.
FAU - Wu, Junzi
AU  - Wu J
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, PR China.
FAU - Wu, Jianrong
AU  - Wu J
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, PR China.
FAU - Niu, Shiwei
AU  - Niu S
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, PR China.
FAU - Li, Heyu
AU  - Li H
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, PR China.
FAU - Wang, Haijun
AU  - Wang H
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, PR China.
FAU - Zhu, Limin
AU  - Zhu L
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, PR China. Electronic address: lzhu@dhu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171006
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 1398-61-4 (Chitin)
RN  - 9004-34-6 (Cellulose)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/adverse effects/*chemical synthesis
MH  - Cell Line
MH  - Cellulose/*analogs & derivatives
MH  - Chitin/*analogs & derivatives
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nanoparticles/*chemistry
MH  - Polysaccharides, Bacterial/chemistry
MH  - *Sutures
MH  - Tensile Strength
OTO - NOTNLM
OT  - Bacterial cellulose nanocrystals
OT  - Biocompatibility
OT  - Regenerated chitin fiber
OT  - Suture biomaterial
EDAT- 2017/11/07 06:00
MHDA- 2018/08/31 06:00
CRDT- 2017/11/07 06:00
PHST- 2017/06/17 00:00 [received]
PHST- 2017/08/15 00:00 [revised]
PHST- 2017/10/04 00:00 [accepted]
PHST- 2017/11/07 06:00 [entrez]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
AID - S0144-8617(17)31168-2 [pii]
AID - 10.1016/j.carbpol.2017.10.022 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2018 Jan 15;180:304-313. doi: 10.1016/j.carbpol.2017.10.022. 
      Epub 2017 Oct 6.