PMID- 29104477
OWN - NLM
STAT- MEDLINE
DCOM- 20180621
LR  - 20181113
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 14
IP  - 12
DP  - 2017
TI  - Water Soluble Vitamins Enhance the Growth of Microorganisms in Peripheral 
      Parenteral Nutrition Solutions.
PG  - 1213-1219
LID - 10.7150/ijms.21424 [doi]
AB  - Peripheral parenteral nutrition (PPN) solutions contain amino acids, glucose, and 
      electrolytes, with or without some water soluble vitamins. Peripheral venous 
      catheters are one of the causes of catheter related blood stream infection 
      (CRBSI), which requires infection control. In Japan, PPN solutions have rarely 
      been prepared under aseptic conditions. However, in recent years, the necessity 
      of adding vitamins to infusions has been reported. Therefore, we investigated the 
      effects of water soluble vitamins on growth of microorganisms in PPN solutions. 
      AMINOFLUID((R)) (AF), BFLUID((R)) (BF), PARESAFE((R)) (PS) and PAREPLUS((R)) (PP) PPN 
      solutions were used. Water soluble vitamins contained in PP were also used. 
      Causative microorganisms of CRBSI were used. Staphylococcus epidermidis decreased 
      after 24 hours or 48 hours in all solutions. On the other hand, Escherichia coli, 
      Serratia marcescens, Pseudomonas aeruginosa, Staphylococcus aureus and Candida 
      albicans increased, especially in PP. When each water soluble vitamin was added 
      to BF and PS, growth of S. aureus was greater in solutions that contained 
      nicotinamide than in solutions that contained other vitamins. As for C. albicans, 
      they grew in all test solutions. C. albicans grew especially well in solutions 
      that contained biotin. When commercial amino acids and glucose solutions with 
      electrolytes are administered, in particular those containing multivitamins or 
      water soluble vitamins, efforts to control infection must be taken to prevent 
      proliferation of microorganisms.
FAU - Omotani, Sachiko
AU  - Omotani S
AD  - Laboratory of Practical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, 
      Osaka Ohtani University.
FAU - Tani, Katsuji
AU  - Tani K
AD  - Laboratory of Environmental Science and Microbiology, Faculty of Pharmacy, Osaka 
      Ohtani University.
FAU - Nagai, Katsuhito
AU  - Nagai K
AD  - Laboratory of Practical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, 
      Osaka Ohtani University.
FAU - Hatsuda, Yasutoshi
AU  - Hatsuda Y
AD  - Laboratory of Practical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, 
      Osaka Ohtani University.
FAU - Mukai, Junji
AU  - Mukai J
AD  - Laboratory of Practical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, 
      Osaka Ohtani University.
FAU - Myotoku, Michiaki
AU  - Myotoku M
AD  - Laboratory of Practical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, 
      Osaka Ohtani University.
LA  - eng
PT  - Journal Article
DEP - 20170919
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Parenteral Nutrition Solutions)
RN  - 0 (Vitamins)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Bacteria/drug effects/*growth & development/isolation & purification
MH  - Catheter-Related Infections/etiology/*prevention & control
MH  - Cell Proliferation/drug effects
MH  - Drug Contamination/*prevention & control
MH  - Fungi/drug effects/*growth & development/isolation & purification
MH  - Humans
MH  - Infection Control/methods/standards
MH  - Japan
MH  - Parenteral Nutrition/adverse effects
MH  - Parenteral Nutrition Solutions/*adverse effects/chemistry/standards
MH  - Solubility
MH  - Vascular Access Devices/microbiology
MH  - Vitamins/chemistry/*pharmacology
MH  - Water/chemistry
PMC - PMC5666554
OTO - NOTNLM
OT  - Peripheral parenteral nutrition
OT  - bacteria
OT  - catheter related blood stream infection
OT  - fungi.
OT  - water soluble vitamin
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2017/11/07 06:00
MHDA- 2018/06/22 06:00
PMCR- 2017/01/01
CRDT- 2017/11/07 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/11/07 06:00 [entrez]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/06/22 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - ijmsv14p1213 [pii]
AID - 10.7150/ijms.21424 [doi]
PST - epublish
SO  - Int J Med Sci. 2017 Sep 19;14(12):1213-1219. doi: 10.7150/ijms.21424. eCollection 
      2017.