PMID- 2910522
OWN - NLM
STAT- MEDLINE
DCOM- 19890217
LR  - 20190510
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 10
IP  - 1
DP  - 1989 Jan
TI  - Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the 
      ring hydrolysis products of barbiturate tumor promoters phenobarbital and 
      barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
PG  - 189-94
AB  - The ring hydrolysis products of the multi-tissue tumor promoting barbiturates, 
      phenobarbital (PB) and barbital (BB), were fed to F344/NCr male rats previously 
      given a single initiating injection of N-nitrosodiethylamine. 
      Ethylphenylacetylurea (EPAU) and diethylacetylurea (EEAU), derived, respectively, 
      from PB and BB, both promoted development of hepatocellular adenomas, but were 
      much weaker in this respect than PB. Both acetylureas were also selective 
      inducers of P-450IIB1-mediated benzyloxyresorufin O-dealkylase activity, but both 
      were much less potent inducers than PB. Neither EPAU nor EEAU had an effect on 
      tumor development in the thyroid, unlike both PB and, as shown previously, BB. 
      EEAU, but not EPAU, strongly promoted development of renal cortical epithelial 
      tumors. The opening of the barbiturate heterocyclic ring and the subsequent 
      decarboxylation to yield the dialkylacetylurea analogs thus resulted in compounds 
      displaying a marked reduction in liver tumor promoting activity. EEAU appears to 
      possess an ability to promote renal neoplasms similar to that of its parent 
      compound, BB. Ring opening appears to be accompanied by loss of promoting 
      activity for thyroid follicular epithelium.
FAU - Diwan, B A
AU  - Diwan BA
AD  - Biological Carcinogenesis & Development Program, Program Resources, Inc., 
      Frederick, MD.
FAU - Nims, R W
AU  - Nims RW
FAU - Ward, J M
AU  - Ward JM
FAU - Hu, H
AU  - Hu H
FAU - Lubet, R A
AU  - Lubet RA
FAU - Rice, J M
AU  - Rice JM
LA  - eng
GR  - N01-CO-74102/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Carcinogens)
RN  - 2274-01-3 (diethylacetylurea)
RN  - 3IQ78TTX1A (Diethylnitrosamine)
RN  - 5WZ53ENE2P (Barbital)
RN  - 878CEJ4HGX (pheneturide)
RN  - 8W8T17847W (Urea)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Animals
MH  - Barbital/analogs & derivatives
MH  - Body Weight
MH  - *Carcinogens
MH  - Cytochrome P-450 Enzyme System/metabolism
MH  - Diethylnitrosamine/*toxicity
MH  - Enzyme Induction/drug effects
MH  - Kidney Neoplasms/*chemically induced
MH  - Liver Neoplasms/*chemically induced
MH  - Phenobarbital/analogs & derivatives
MH  - Rats
MH  - Rats, Inbred F344
MH  - Thyroid Neoplasms/chemically induced
MH  - Urea/*analogs & derivatives/toxicity
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1093/carcin/10.1.189 [doi]
PST - ppublish
SO  - Carcinogenesis. 1989 Jan;10(1):189-94. doi: 10.1093/carcin/10.1.189.