PMID- 29105530
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20180918
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 34
IP  - 4
DP  - 2018 Apr
TI  - The relationship between IL-18 and atherosclerotic cardiovascular risk in 
      Egyptian lean women with polycystic ovary syndrome.
PG  - 294-297
LID - 10.1080/09513590.2017.1395835 [doi]
AB  - BACKGROUND: Polycystic ovarian syndrome (PCOS) is the most common endocrine 
      disorder among women of reproductive age. The evidence in support of low-grade 
      inflammation in PCOS as an etiology is emerging. Inflammation is likely to be 
      associated with other prominent aspects of PCOS including insulin resistance (IR) 
      and cardiovascular disease (CVD) risk. Interleukin-18 (IL-18) is considered as a 
      strong marker of inflammation. OBJECTIVES: Evaluation of the relation between 
      serum IL-18 and atherosclerotic CVD (ASCVD) risk in Egyptian lean females with 
      PCO. METHODS: This study included control group of healthy lean normally 
      menstruating females, lean PCOS group (BMI < 25 kg/m(2)), and obese PCOS group 
      (BMI > 25 kg/m(2)) presented with infertility and diagnosed according to 
      Rotterdam criteria. Measurements of serum lipid profile, IR, and IL-18 were done. 
      RESULTS: Lipid accumulation product (LAP), IR and ASCVD risk were significantly 
      higher in PCOS patients (lean and obese) compared to controls and in obese 
      compared to lean. Serum IL-18 was significantly higher in the PCOV groups 
      compared to the controls and correlated directly with LAP, IR and ASCVD risk. 
      CONCLUSION: IL-18 is elevated in PCOS patients even in lean ones and is 
      correlated with IR and ASCVD risk.
FAU - Dawood, Alaaeldin
AU  - Dawood A
AD  - a Internal Medicine , Menoufia University , Shebin El-Kom , Egypt.
FAU - Alkafrawy, Nabil
AU  - Alkafrawy N
AD  - a Internal Medicine , Menoufia University , Shebin El-Kom , Egypt.
FAU - Saleh, Said
AU  - Saleh S
AD  - b Obstetrics and Gynecology , Faculty of Medicine-Menoufia University , Shebin 
      El-Kom , Egypt.
FAU - Noreldin, Rasha
AU  - Noreldin R
AD  - c Clinical Pathology , Menoufia University , Shebin El-Kom , Egypt.
FAU - Zewain, Shimaa
AU  - Zewain S
AD  - a Internal Medicine , Menoufia University , Shebin El-Kom , Egypt.
LA  - eng
PT  - Journal Article
DEP - 20171105
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Atherosclerosis/blood/*etiology
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Egypt
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Interleukin-18/*blood
MH  - Polycystic Ovary Syndrome/blood/*complications
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Polycystic ovary
OT  - cardiovascular disease risk
OT  - interleukin-18
EDAT- 2017/11/07 06:00
MHDA- 2018/09/19 06:00
CRDT- 2017/11/07 06:00
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
AID - 10.1080/09513590.2017.1395835 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2018 Apr;34(4):294-297. doi: 10.1080/09513590.2017.1395835. 
      Epub 2017 Nov 5.