PMID- 29105605
OWN - NLM
STAT- MEDLINE
DCOM- 20181016
LR  - 20240318
IS  - 1945-5119 (Electronic)
IS  - 1074-9357 (Print)
IS  - 1074-9357 (Linking)
VI  - 25
IP  - 2
DP  - 2018 Mar
TI  - The feasibility of an acute high-intensity exercise bout to promote locomotor 
      learning after stroke.
PG  - 83-89
LID - 10.1080/10749357.2017.1399527 [doi]
AB  - BACKGROUND: People post-stroke can learn a novel locomotor task but require more 
      practice to do so. Implementing an approach that can enhance locomotor learning 
      may therefore improve post-stroke locomotor recovery. In healthy adults, an acute 
      high-intensity exercise bout before or after a motor task may improve motor 
      learning and has thus been suggested as a method that could be used to improve 
      motor learning in neurorehabilitation. However, it is unclear whether an acute 
      high-intensity exercise bout, which stroke survivors can feasibly complete in 
      neurorehabilitation session, would generate comparable results. OBJECTIVE: To 
      determine a feasible, high-intensity exercise protocol that could be incorporated 
      into a post-stroke neurorehabilitation session and would result in significant 
      exercise-induced responses. METHODS: Thirty-seven chronic stroke survivors 
      participated. We allocated subjects to either a control (CON) or one of the 
      exercise groups: treadmill walking (TMW), and total body exercise (TBE). The main 
      exercise-induced measures were: average intensity (% max intensity) and time 
      spent (absolute: seconds; normalized: % total time) at target exercise intensity, 
      and magnitudes of change in serum lactate (mmol/l) and brain-derived neurotrophic 
      factor (BDNF; ng/ml). RESULTS: Compared to CON, both exercise groups reached and 
      exercised longer at their target intensities and had greater responses in 
      lactate. However, the TBE group exercised longer at target intensity and with 
      greater lactate response than the TMW group. There were no significant BDNF 
      responses among groups. CONCLUSIONS: An acute high-intensity exercise bout that 
      could be incorporated into a neurorehabilitation learning-specific session and 
      results in substantial exercise-induced responses is feasible post-stroke.
FAU - Charalambous, Charalambos C
AU  - Charalambous CC
AUID- ORCID: 0000-0002-1547-1839
AD  - a Department of Physical Therapy , University of Delaware , Newark , DE , USA.
FAU - Helm, Erin E
AU  - Helm EE
AD  - a Department of Physical Therapy , University of Delaware , Newark , DE , USA.
AD  - b Biomechanics and Movement Science Program , University of Delaware , Newark , 
      DE , USA.
FAU - Lau, Kristin A
AU  - Lau KA
AD  - a Department of Physical Therapy , University of Delaware , Newark , DE , USA.
FAU - Morton, Susanne M
AU  - Morton SM
AD  - a Department of Physical Therapy , University of Delaware , Newark , DE , USA.
AD  - b Biomechanics and Movement Science Program , University of Delaware , Newark , 
      DE , USA.
FAU - Reisman, Darcy S
AU  - Reisman DS
AD  - a Department of Physical Therapy , University of Delaware , Newark , DE , USA.
AD  - b Biomechanics and Movement Science Program , University of Delaware , Newark , 
      DE , USA.
LA  - eng
GR  - R01 HD078330/HD/NICHD NIH HHS/United States
GR  - S10 RR028114/RR/NCRR NIH HHS/United States
GR  - T32 HD007490/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20171105
PL  - England
TA  - Top Stroke Rehabil
JT  - Topics in stroke rehabilitation
JID - 9439750
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Exercise Test
MH  - Female
MH  - High-Intensity Interval Training/*methods
MH  - Humans
MH  - Learning/*physiology
MH  - Locomotion/*physiology
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Stroke/blood/*complications/diagnostic imaging
MH  - *Stroke Rehabilitation
MH  - Young Adult
PMC - PMC5901747
MID - NIHMS957778
OTO - NOTNLM
OT  - Stroke
OT  - brain-derived neurotrophic factor
OT  - lactate
OT  - motor learning
OT  - priming
OT  - rehabilitation
COIS- Declaration of Conflicting Interests The authors report no conflicts of interest.
EDAT- 2017/11/07 06:00
MHDA- 2018/10/17 06:00
PMCR- 2019/03/01
CRDT- 2017/11/07 06:00
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/10/17 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 10.1080/10749357.2017.1399527 [doi]
PST - ppublish
SO  - Top Stroke Rehabil. 2018 Mar;25(2):83-89. doi: 10.1080/10749357.2017.1399527. 
      Epub 2017 Nov 5.