PMID- 29106481 OWN - NLM STAT- MEDLINE DCOM- 20190508 LR - 20190508 IS - 1476-6256 (Electronic) IS - 0002-9262 (Linking) VI - 187 IP - 3 DP - 2018 Mar 1 TI - Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals. PG - 494-506 LID - 10.1093/aje/kwx267 [doi] AB - Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes-particularly, among individuals with a similar body mass index-could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, beta-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals. FAU - Gasull, Magda AU - Gasull M AD - Grup de Recerca en Epidemiologia Clinica i Molecular del Cancer. AD - Centro de Investigacion Biomedica en Red-Epidemiologia y Salud Publica. AD - Department of Preventive Medicine and Public Health, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Castell, Conxa AU - Castell C AD - Department of Health, Generalitat de Catalunya, Barcelona, Spain. FAU - Pallares, Natalia AU - Pallares N AD - Grup de Recerca en Epidemiologia Clinica i Molecular del Cancer. AD - Centro de Investigacion Biomedica en Red-Epidemiologia y Salud Publica. AD - Department of Preventive Medicine and Public Health, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Miret, Carme AU - Miret C AD - Grup de Recerca en Epidemiologia Clinica i Molecular del Cancer. AD - Department of Preventive Medicine and Public Health, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Pumarega, Jose AU - Pumarega J AD - Grup de Recerca en Epidemiologia Clinica i Molecular del Cancer. AD - Centro de Investigacion Biomedica en Red-Epidemiologia y Salud Publica. FAU - Te Llez-Plaza, Maria AU - Te Llez-Plaza M AD - Institute for Biomedical Research, Hospital Clinic de Valencia. AD - Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Lopez, Tomas AU - Lopez T AD - Grup de Recerca en Epidemiologia Clinica i Molecular del Cancer. AD - Centro de Investigacion Biomedica en Red-Epidemiologia y Salud Publica. AD - Department of Preventive Medicine and Public Health, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Center, Rovira i Virgili University, Reus, Spain. AD - Centro de Investigacion Biomedica en Red-Fisiopatologia de la Obesidad y Nutricion. FAU - Lee, Duk-Hee AU - Lee DH AD - Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. FAU - Goday, Albert AU - Goday A AD - Department of Preventive Medicine and Public Health, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red-Fisiopatologia de la Obesidad y Nutricion. AD - Department of Endocrinology and Nutrition, Hospital del Mar. FAU - Porta, Miquel AU - Porta M AD - Grup de Recerca en Epidemiologia Clinica i Molecular del Cancer. AD - Centro de Investigacion Biomedica en Red-Epidemiologia y Salud Publica. AD - Department of Preventive Medicine and Public Health, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Epidemiol JT - American journal of epidemiology JID - 7910653 RN - 0 (Environmental Pollutants) RN - 4Z87H0LKUY (Hexachlorobenzene) RN - 59NEE7PCAB (Hexachlorocyclohexane) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - YM80ODM9PD (beta-hexachlorocyclohexane) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Body Weight MH - Environmental Pollutants/*blood MH - Female MH - Hexachlorobenzene/blood MH - Hexachlorocyclohexane/blood MH - Humans MH - Male MH - Metabolic Syndrome/*blood MH - Middle Aged MH - Obesity/*blood MH - Overweight/*blood MH - *Phenotype MH - Polychlorinated Biphenyls/blood MH - Prevalence MH - Risk Factors MH - Spain/epidemiology MH - Surveys and Questionnaires MH - Young Adult EDAT- 2017/11/07 06:00 MHDA- 2019/05/09 06:00 CRDT- 2017/11/07 06:00 PHST- 2016/09/15 00:00 [received] PHST- 2017/06/23 00:00 [accepted] PHST- 2017/11/07 06:00 [pubmed] PHST- 2019/05/09 06:00 [medline] PHST- 2017/11/07 06:00 [entrez] AID - 3903147 [pii] AID - 10.1093/aje/kwx267 [doi] PST - ppublish SO - Am J Epidemiol. 2018 Mar 1;187(3):494-506. doi: 10.1093/aje/kwx267.