PMID- 29106694
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20191210
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 44
IP  - 3
DP  - 2018 Apr 6
TI  - Episodic Memory for Dynamic Social Interaction Across Phase of Illness in 
      Schizophrenia.
PG  - 620-630
LID - 10.1093/schbul/sbx081 [doi]
AB  - Although a number of studies examined recollection and familiarity memory in 
      schizophrenia, most of studies have focused on nonsocial episodic memory. Little 
      is known about how schizophrenia patients remember social information in everyday 
      life and whether social episodic memory changes over the course of illness. This 
      study aims to examine episodic memory for dynamic social interaction with 
      multimodal social stimuli in schizophrenia across phase of illness. Within each 
      phase of illness, probands and demographically matched controls participated: 51 
      probands at clinical high risk (CHR) for psychosis and 36 controls, 80 
      first-episode schizophrenia patients and 49 controls, and 50 chronic 
      schizophrenia patients and 39 controls. The participants completed the Social 
      Remember-Know Paradigm that assessed overall social episodic memory, social 
      recollection and familiarity memory, and social context memory, in addition to 
      social cognitive measures and measures on community functioning. Probands showed 
      impairment for recollection but not in familiarity memory and this pattern was 
      similar across phase of illness. In contrast, impaired social context memory was 
      observed in the first-episode and chronic schizophrenia samples, but not in CHR 
      samples. Social context memory was associated with community functioning only in 
      the chronic sample. These findings suggest that an impaired recollection could be 
      a vulnerability marker for schizophrenia whereas impaired social context memory 
      could be a disease-related marker. Further, a pattern of impaired recollection 
      with intact familiarity memory for social stimuli suggests that schizophrenia 
      patients may have a different pattern of impaired episodic memory for social vs 
      nonsocial stimuli.
FAU - Lee, Junghee
AU  - Lee J
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA.
FAU - Nuechterlein, Keith H
AU  - Nuechterlein KH
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
AD  - Department of Psychology, University of California Los Angeles, Los Angeles, CA.
FAU - Knowlton, Barbara J
AU  - Knowlton BJ
AD  - Department of Psychology, University of California Los Angeles, Los Angeles, CA.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
AD  - Department of Psychology, University of California Los Angeles, Los Angeles, CA.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, CT.
FAU - Fiske, Alan P
AU  - Fiske AP
AD  - Department of Anthropology, University of California Los Angeles, Los Angeles, 
      CA.
FAU - Ghermezi, Livon
AU  - Ghermezi L
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
FAU - Hayata, Jacqueline N
AU  - Hayata JN
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
FAU - Hellemann, Gerhard S
AU  - Hellemann GS
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
FAU - Horan, William P
AU  - Horan WP
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA.
FAU - Kee, Kimmy
AU  - Kee K
AD  - Department of Psychology, California State University Channel Islands, Los 
      Angeles, CA.
FAU - Kern, Robert S
AU  - Kern RS
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA.
FAU - Subotnik, Kenneth L
AU  - Subotnik KL
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
FAU - Sugar, Catherine A
AU  - Sugar CA
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
FAU - Ventura, Joseph
AU  - Ventura J
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
FAU - Yee, Cindy M
AU  - Yee CM
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
AD  - Department of Psychology, University of California Los Angeles, Los Angeles, CA.
FAU - Green, Michael F
AU  - Green MF
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA.
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA.
LA  - eng
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Memory Disorders/*physiopathology
MH  - *Memory, Episodic
MH  - Mental Recall/*physiology
MH  - Middle Aged
MH  - Recognition, Psychology/*physiology
MH  - Risk
MH  - Schizophrenia/*physiopathology
MH  - Young Adult
PMC - PMC5890490
EDAT- 2017/11/07 06:00
MHDA- 2018/12/12 06:00
PMCR- 2019/04/06
CRDT- 2017/11/07 06:00
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
PHST- 2019/04/06 00:00 [pmc-release]
AID - 3929965 [pii]
AID - sbx081 [pii]
AID - 10.1093/schbul/sbx081 [doi]
PST - ppublish
SO  - Schizophr Bull. 2018 Apr 6;44(3):620-630. doi: 10.1093/schbul/sbx081.