PMID- 29106903
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20180806
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 818
DP  - 2018 Jan 5
TI  - Crocin attenuates acute hypobaric hypoxia-induced cognitive deficits of rats.
PG  - 300-305
LID - S0014-2999(17)30695-7 [pii]
LID - 10.1016/j.ejphar.2017.10.042 [doi]
AB  - This study investigated whether crocin exerted neuroprotective effects against 
      acute hypobaric hypoxia at high altitude in vivo and determined the underlying 
      mechanisms. Male Sprague-Dawley rats were randomly assigned to a normoxic group，a 
      hypoxic group, and three crocin groups at three different doses. The rats were 
      transferred from 50m to 4200m for 3 days after treatment with crocin for 3 days. 
      The learning and memory of the rat were evaluated with the Morris water maze 
      test. Transmission electron microscope (TEM) was used to analyze the changes in 
      the ultrastructure of hippocampal neurons. Peroxisome proliferator-activated 
      receptor-gamma co-activator 1alpha (PGC-1alpha) and sirtuin-1 (SIRT1) levels were determined 
      using immunohistochemical staining and western blotting. The escape latency of 
      the crocin group was shorter than that of the hypoxic group, while the frequency 
      of the rats reaching the platform was significantly higher in the crocin group. 
      The structures of nerve cells and mitochondria were destroyed in the hypoxic 
      group, but were repaired in the crocin groups. The expressions of PGC-1alpha and 
      SIRT1 were decreased in the hypoxic group, but were increased in the crocin 
      group. All the effects improved by crocin were dose-dependent. Crocin attenuates 
      acute hypobaric hypoxia-induced cognitive deficits in rats, accompanied by 
      repairing the structures of hippocampal neurons and improving PGC-1alpha and SIRT1 
      levels.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Zhang, Xiao-Yan
AU  - Zhang XY
AD  - Department of Basic Medicine Science, Medical College of Qinghai University, 
      Xining 810001, China. Electronic address: zxy82164@163.com.
FAU - Zhang, Xian-Jun
AU  - Zhang XJ
AD  - Department of Basic Medicine Science, Medical College of Qinghai University, 
      Xining 810001, China.
FAU - Xv, Jin
AU  - Xv J
AD  - Department of Basic Medicine Science, Medical College of Qinghai University, 
      Xining 810001, China.
FAU - Jia, Wei
AU  - Jia W
AD  - Department of Basic Medicine Science, Medical College of Qinghai University, 
      Xining 810001, China.
FAU - Pu, Xiao-Yan
AU  - Pu XY
AD  - Department of Basic Medicine Science, Medical College of Qinghai University, 
      Xining 810001, China.
FAU - Wang, Hai-Yan
AU  - Wang HY
AD  - Department of Basic Medicine Science, Medical College of Qinghai University, 
      Xining 810001, China.
FAU - Liang, Hong
AU  - Liang H
AD  - Department of Basic Medicine Science, Medical College of Qinghai University, 
      Xining 810001, China.
FAU - Zhuoma-Lamao
AU  - Zhuoma-Lamao
AD  - Department of Respiratory, Qinghai Red Cross Hospital, Xining 810000, Qinghai 
      Province, China.
FAU - Lu, Dian-Xiang
AU  - Lu DX
AD  - Research center of high altitude medicine, Qinghai University Medical College, 
      Xining 810000, China.
LA  - eng
PT  - Journal Article
DEP - 20171026
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - 36-88-4 (Carotenoids)
RN  - 877GWI46C2 (crocin)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Carotenoids/*pharmacology/therapeutic use
MH  - Cognition Disorders/*complications/*drug therapy/pathology/physiopathology
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/pathology/physiopathology
MH  - Hypoxia/*complications
MH  - Male
MH  - Maze Learning/drug effects
MH  - Neurons/drug effects/metabolism/ultrastructure
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
MH  - Protein Transport/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sirtuin 1/metabolism
OTO - NOTNLM
OT  - Acute hypobaric hypoxia
OT  - Cognitive deficits
OT  - Crocin
OT  - Hippocampus
OT  - PGC-1alpha
OT  - SIRT1
EDAT- 2017/11/07 06:00
MHDA- 2018/08/07 06:00
CRDT- 2017/11/07 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/10/16 00:00 [revised]
PHST- 2017/10/20 00:00 [accepted]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
AID - S0014-2999(17)30695-7 [pii]
AID - 10.1016/j.ejphar.2017.10.042 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2018 Jan 5;818:300-305. doi: 10.1016/j.ejphar.2017.10.042. Epub 
      2017 Oct 26.