PMID- 29107106
OWN - NLM
STAT- MEDLINE
DCOM- 20171205
LR  - 20210109
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 412
DP  - 2018 Jan 1
TI  - The role of nitric oxide in metabolic regulation of Dendritic cell immune 
      function.
PG  - 236-242
LID - S0304-3835(17)30669-9 [pii]
LID - 10.1016/j.canlet.2017.10.032 [doi]
AB  - Dendritic cells (DCs) are canonical antigen presenting cells of the immune system 
      and serve as a bridge between innate and adaptive immune responses. When DCs are 
      activated by a stimulus through toll-like receptors (TLRs), DCs undergo a process 
      of maturation defined by cytokine & chemokine secretion, co-stimulatory molecule 
      expression, antigen processing and presentation, and the ability to activate T 
      cells. DC maturation is coupled with an increase in biosynthetic demand, which is 
      fulfilled by a TLR-driven upregulation in glycolytic metabolism. Up-regulation of 
      glycolysis in activated DCs provides these cells with molecular building blocks 
      and cellular energy required for DC activation, and inhibition of glycolysis 
      during initial activation impairs both the survival and effector function of 
      activated DCs. Evidence shows that DC glycolytic upregulation is controlled by 
      two distinct pathways, an early burst of glycolysis that is nitric oxide (NO) 
      -independent, and a sustained commitment to glycolysis in NO-producing DC 
      subsets. This review will address the complex role of NO in regulating DC 
      metabolism and effector function.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Thwe, Phyu M
AU  - Thwe PM
AD  - Cell, Molecular, and Biomedical Sciences Program, University of Vermont, 
      Burlington, VT 05405, USA; Department of Medical Laboratory and Radiation 
      Sciences, College of Nursing and Health Sciences, University of Vermont, 
      Burlington, VT 05405, USA.
FAU - Amiel, Eyal
AU  - Amiel E
AD  - Cell, Molecular, and Biomedical Sciences Program, University of Vermont, 
      Burlington, VT 05405, USA; Department of Medical Laboratory and Radiation 
      Sciences, College of Nursing and Health Sciences, University of Vermont, 
      Burlington, VT 05405, USA. Electronic address: Eyal.Amiel@med.uvm.edu.
LA  - eng
GR  - P20 RR021905/RR/NCRR NIH HHS/United States
GR  - P30 GM118228/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171026
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Apoptosis
MH  - Cellular Reprogramming
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Glycolysis
MH  - Humans
MH  - Lymphocyte Activation
MH  - Nitric Oxide/*physiology
MH  - T-Lymphocytes/immunology
PMC - PMC5699934
MID - NIHMS918133
EDAT- 2017/11/07 06:00
MHDA- 2017/12/06 06:00
PMCR- 2019/01/01
CRDT- 2017/11/07 06:00
PHST- 2017/07/12 00:00 [received]
PHST- 2017/09/30 00:00 [revised]
PHST- 2017/10/22 00:00 [accepted]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2017/12/06 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - S0304-3835(17)30669-9 [pii]
AID - 10.1016/j.canlet.2017.10.032 [doi]
PST - ppublish
SO  - Cancer Lett. 2018 Jan 1;412:236-242. doi: 10.1016/j.canlet.2017.10.032. Epub 2017 
      Oct 26.