PMID- 29107350
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20181202
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 110
DP  - 2018 Jan
TI  - Dynamics of persistent organic pollutants in obese adolescents during weight 
      loss.
PG  - 80-87
LID - S0160-4120(17)31613-6 [pii]
LID - 10.1016/j.envint.2017.10.009 [doi]
AB  - We have investigated the dynamics of various persistent organic pollutants (POPs) 
      in the serum of 94 obese adolescents (34 boys and 60 girls: age range 11-19years) 
      before (0M) and after 5months (5M) of undergoing weight loss treatment. Six 
      groups of POPs, such as polychlorinated biphenyls (PCBs), 
      dichlorodiphenyltrichloroethane and its metabolites (DDTs), chlordane compounds 
      (CHLs), hexachlorocyclohexane isomers (HCHs), hexachlorobenzene (HCB) and 
      polybrominated diphenyl ethers (PBDEs), were detected in all samples in the 
      decreasing order of median levels: DDTs>PCBs>HCB>HCHs>CHLs>PBDEs. Levels and 
      patterns of POPs between boys and girls at two time-points were similar. DDTs 
      (0M/5M; median: 31/42ng/g lw) and PCBs (0M/5M; median: 17/28ng/g lw) were the 
      major POPs. PCB 153 (0M/5M; 33/34% of the sum PCBs) was the most dominant PCB 
      congener, followed by PCB 138 (0M/5M; 31/31%) and PCB 180 (0M/5M; 13/12%), 
      respectively. The most important PBDE congeners were BDE 47 and 153, although 
      total PBDE levels were low and ranged between 0.63 and 0.88ng/g lw. In general, 
      levels of POPs in the obese adolescents were lower than previously reported in 
      Belgian adolescents and adults. Due to weight loss, serum levels (except PBDEs) 
      increased significantly thereafter combined with a body weight decrease (from 4 
      to 42kg). Serum concentrations increased by 1-3.5% per kilogram weight loss and 
      1-2.5% per BMI z-score loss for most POPs. To our knowledge, this is the first 
      report on the dynamics of POPs in obese adolescents during weight loss. 
      Lipid-soluble contaminants were released from adipose tissue into the blood 
      leading to redistribution into the body. Whether the increase in the internal 
      exposure to POPs may adversely influence health remains to be determined.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Malarvannan, Govindan
AU  - Malarvannan G
AD  - Toxicological Centre, University of Antwerp, Universiteitsplein 1, Wilrijk, 
      Belgium. Electronic address: malarvannan.govindan@uantwerpen.be.
FAU - Van Hoorenbeeck, Kim
AU  - Van Hoorenbeeck K
AD  - Department of Pediatrics, Laboratory of Experimental Medicine and Pediatrics, 
      Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
FAU - Deguchtenaere, Ann
AU  - Deguchtenaere A
AD  - Zeepreventorium, De Haan, Belgium.
FAU - Verhulst, Stijn L
AU  - Verhulst SL
AD  - Department of Pediatrics, Laboratory of Experimental Medicine and Pediatrics, 
      Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
FAU - Dirinck, Eveline
AU  - Dirinck E
AD  - Departments of Endocrinology, Diabetology and Metabolism, Antwerp University 
      Hospital, University of Antwerp, Edegem, Belgium.
FAU - Van Gaal, Luc
AU  - Van Gaal L
AD  - Departments of Endocrinology, Diabetology and Metabolism, Antwerp University 
      Hospital, University of Antwerp, Edegem, Belgium.
FAU - Jorens, Philippe G
AU  - Jorens PG
AD  - Department of Clinical Pharmacology, Antwerp University Hospital, University of 
      Antwerp, Edegem, Belgium.
FAU - Covaci, Adrian
AU  - Covaci A
AD  - Toxicological Centre, University of Antwerp, Universiteitsplein 1, Wilrijk, 
      Belgium. Electronic address: adrian.covaci@uantwerpen.be.
LA  - eng
PT  - Journal Article
DEP - 20171026
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Adolescent
MH  - Belgium
MH  - Child
MH  - Cholesterol/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Pediatric Obesity/blood/*metabolism
MH  - Prospective Studies
MH  - *Weight Loss
MH  - Young Adult
OTO - NOTNLM
OT  - Belgium
OT  - Obese adolescents
OT  - PBDEs
OT  - Persistent organic pollutants
OT  - Weight loss
EDAT- 2017/11/07 06:00
MHDA- 2018/03/13 06:00
CRDT- 2017/11/07 06:00
PHST- 2017/09/08 00:00 [received]
PHST- 2017/10/15 00:00 [revised]
PHST- 2017/10/19 00:00 [accepted]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
AID - S0160-4120(17)31613-6 [pii]
AID - 10.1016/j.envint.2017.10.009 [doi]
PST - ppublish
SO  - Environ Int. 2018 Jan;110:80-87. doi: 10.1016/j.envint.2017.10.009. Epub 2017 Oct 
      26.