PMID- 29107739
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20180725
IS  - 1477-2566 (Electronic)
IS  - 1465-3249 (Linking)
VI  - 19
IP  - 12
DP  - 2017 Dec
TI  - Comparative restoration of acute liver failure by menstrual blood stem cells 
      compared with bone marrow stem cells in mice model.
PG  - 1474-1490
LID - S1465-3249(17)30696-5 [pii]
LID - 10.1016/j.jcyt.2017.08.022 [doi]
AB  - BACKGROUND AIMS: The application of menstrual blood stem cells (MenSCs) in 
      regenerative medicine is gaining increasing attention. The aim of this study was 
      to investigate the therapeutic potential of MenSCs compared with bone 
      marrow-derived stem cells (BMSCs) in an animal model of CCl(4)-induced acute 
      hepatic failure. METHODS: Injured Balb/C mice were divided into multiple groups 
      and received MenSCs, BMSCs or hepatocyte progenitor-like (HPL) cells derived from 
      these cells. RESULTS: Tracking of green fluorescent protein-labeled cells showed 
      homing of cells in injured areas of the liver. In addition, the liver engraftment 
      of MenSCs was shown by immunofluorescence staining using anti-human mitochondrial 
      antibody. Microscopically examination, periodic acid-Schiff and Masson's 
      trichrome staining of liver sections demonstrated the considerable liver 
      regeneration post-cell therapy in all groups. Assessment of serum parameters 
      including aspartate aminotransferase, alanine aminotransferase, total bilirubin, 
      urea and cholesterol at day 7 exhibited significant reduction, such that this 
      downward trend continued significantly until day 30. The restoration of liver 
      biochemical markers, changes in mRNA levels of hepatic markers and the 
      suppression of inflammatory markers were more significant in the MenSC-treated 
      group compared with the BMSC-treated group. On the other hand, HPL cells in 
      reference to undifferentiated cells had better effectiveness in the treatment of 
      the acute liver injury. CONCLUSIONS: Our data show that MenSCs may be considered 
      an appropriate alternative stem cell population to BMSCs for treatment of acute 
      liver failure.
CI  - Copyright (c) 2017 International Society for Cellular Therapy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Fathi-Kazerooni, Mina
AU  - Fathi-Kazerooni M
AD  - Department of Molecular Medicine, School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Tavoosidana, Gholamreza
AU  - Tavoosidana G
AD  - Department of Molecular Medicine, School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Taghizadeh-Jahed, Masoud
AU  - Taghizadeh-Jahed M
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Khanjani, Sayeh
AU  - Khanjani S
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Golshahi, Hananeh
AU  - Golshahi H
AD  - Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, 
      Tehran, Iran.
FAU - Gargett, Caroline E
AU  - Gargett CE
AD  - The Ritchie Centre, Hudson Institute of Medical Research, and Department of 
      Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia.
FAU - Edalatkhah, Haleh
AU  - Edalatkhah H
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Kazemnejad, Somaieh
AU  - Kazemnejad S
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran. Electronic address: kazemnejad_s@yahoo.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171106
PL  - England
TA  - Cytotherapy
JT  - Cytotherapy
JID - 100895309
RN  - 0 (Biomarkers)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Biomarkers/metabolism
MH  - Bone Marrow Cells/*cytology
MH  - Cell Differentiation
MH  - Disease Models, Animal
MH  - Female
MH  - Hepatocytes/cytology
MH  - Humans
MH  - Liver Failure, Acute/*therapy
MH  - Liver Regeneration
MH  - Menstruation/*blood
MH  - Mice, Inbred BALB C
MH  - Stem Cell Transplantation/*methods
MH  - Stem Cells/cytology
OTO - NOTNLM
OT  - bone marrow stem cells
OT  - liver injury
OT  - menstrual blood stem cells
OT  - regenerative medicine
EDAT- 2017/11/07 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/11/07 06:00
PHST- 2017/03/17 00:00 [received]
PHST- 2017/07/29 00:00 [revised]
PHST- 2017/08/20 00:00 [accepted]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
AID - S1465-3249(17)30696-5 [pii]
AID - 10.1016/j.jcyt.2017.08.022 [doi]
PST - ppublish
SO  - Cytotherapy. 2017 Dec;19(12):1474-1490. doi: 10.1016/j.jcyt.2017.08.022. Epub 
      2017 Nov 6.