PMID- 29107945
OWN - NLM
STAT- MEDLINE
DCOM- 20171128
LR  - 20190118
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 11
DP  - 2017
TI  - Neurogenesis in the olfactory bulb induced by paced mating in the female rat is 
      opioid dependent.
PG  - e0186335
LID - 10.1371/journal.pone.0186335 [doi]
LID - e0186335
AB  - The possibility to control the rate of sexual stimulation that the female rat 
      receives during a mating encounter (pacing) increases the number of newborn 
      neurons that reach the granular layer of the accessory olfactory bulb (AOB). If 
      females mate repeatedly, the increase in the number of neurons is observed in 
      other regions of the AOB and in the main olfactory bulb (MOB). It has also been 
      shown that paced mating induces a reward state mediated by opioids. There is also 
      evidence that opioids modulate neurogenesis. In the present study, we evaluated 
      whether the opioid receptor antagonist naloxone (NX) could reduce the increase in 
      neurogenesis in the AOB induced by paced mating. Ovariectomized female rats were 
      randomly divided in 5 different groups: 1) Control (not mated) treated with 
      saline, 2) control (not mated) treated with naloxone, 3) females that mated 
      without controlling the sexual interaction (no-pacing), 4) females injected with 
      saline before pacing the sexual interaction and 5) females injected with NX 
      before a paced mating session. We found, as previously described, that paced 
      mating induced a higher number of new cells in the granular layer of the AOB. The 
      administration of NX before paced mating, blocked the increase in the number of 
      newborn cells and prevented these cells from differentiating into neurons. These 
      data suggest that opioid peptides play a fundamental role in the neurogenesis 
      induced by paced mating in female rats.
FAU - Santoyo-Zedillo, Marianela
AU  - Santoyo-Zedillo M
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico Campus 
      Juriquilla, Queretaro, Mexico.
FAU - Portillo, Wendy
AU  - Portillo W
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico Campus 
      Juriquilla, Queretaro, Mexico.
FAU - Paredes, Raul G
AU  - Paredes RG
AUID- ORCID: 0000-0002-3032-3527
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico Campus 
      Juriquilla, Queretaro, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20171106
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Opioid Peptides)
RN  - 36B82AMQ7N (Naloxone)
SB  - IM
MH  - Animals
MH  - Female
MH  - Naloxone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Neurogenesis/*physiology
MH  - Olfactory Bulb/*physiology
MH  - Opioid Peptides/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - *Sexual Behavior, Animal
PMC - PMC5673160
COIS- Competing Interests: The authors have declared that no competing interest exist.
EDAT- 2017/11/07 06:00
MHDA- 2017/11/29 06:00
PMCR- 2017/11/06
CRDT- 2017/11/07 06:00
PHST- 2017/06/04 00:00 [received]
PHST- 2017/10/01 00:00 [accepted]
PHST- 2017/11/07 06:00 [entrez]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/11/06 00:00 [pmc-release]
AID - PONE-D-17-21378 [pii]
AID - 10.1371/journal.pone.0186335 [doi]
PST - epublish
SO  - PLoS One. 2017 Nov 6;12(11):e0186335. doi: 10.1371/journal.pone.0186335. 
      eCollection 2017.