PMID- 29108028 OWN - NLM STAT- MEDLINE DCOM- 20171128 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 11 DP - 2017 TI - Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. PG - e0187634 LID - 10.1371/journal.pone.0187634 [doi] LID - e0187634 AB - The identification of growth factors as potential biomarkers in alcohol addiction may help to understand underlying mechanisms associated with the pathogenesis of alcohol use disorders (AUDs). Previous studies have linked growth factors to neural plasticity in neurocognitive impairment and mental disorders. In order to further clarify the impact of chronic alcohol consumption on circulating growth factors, a cross-sectional study was performed in abstinent AUD patients (alcohol group, N = 91) and healthy control subjects (control group, N = 55) to examine plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein-3 (IGFBP-3). The association of these plasma peptides with relevant AUD-related variables and psychiatric comorbidity was explored. The alcohol group was diagnosed with severe AUD and showed an average of 13 years of problematic use and 10 months of abstinence at the moment of participating in the study. Regarding common medical conditions associated with AUD, we observed an elevated incidence of alcohol-induced liver and pancreas diseases (18.7%) and psychiatric comorbidity (76.9%). Thus, AUD patients displayed a high prevalence of dual diagnosis (39.3%) [mainly depression (19.9%)] and comorbid substance use disorders (40.7%). Plasma BDNF and IGF-1 concentrations were significantly lower in the alcohol group than in the control group (p<0.001). Remarkably, there was a negative association between IGF-1 concentrations and age in the control group (r = -0.52, p<0.001) that was not found in the alcohol group. Concerning AUD-related variables, AUD patients with liver and pancreas diseases showed even lower concentrations of BDNF (p<0.05). In contrast, the changes in plasma concentrations of these peptides were not associated with abstinence, problematic use, AUD severity or lifetime psychiatric comorbidity. These results suggest that further research is necessary to elucidate the role of BDNF in alcohol-induced toxicity and the biological significance of the lack of correlation between age and plasma IGF-1 levels in abstinent AUD patients. FAU - Garcia-Marchena, Nuria AU - Garcia-Marchena N AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Silva-Pena, Daniel AU - Silva-Pena D AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Martin-Velasco, Ana Isabel AU - Martin-Velasco AI AD - Departamento de Fisiologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. FAU - Villanua, Maria Angeles AU - Villanua MA AD - Departamento de Fisiologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. FAU - Araos, Pedro AU - Araos P AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Pedraz, Maria AU - Pedraz M AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Maza-Quiroga, Rosa AU - Maza-Quiroga R AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Romero-Sanchiz, Pablo AU - Romero-Sanchiz P AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Rubio, Gabriel AU - Rubio G AD - Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain. FAU - Castilla-Ortega, Estela AU - Castilla-Ortega E AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Suarez, Juan AU - Suarez J AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Rodriguez de Fonseca, Fernando AU - Rodriguez de Fonseca F AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Serrano, Antonia AU - Serrano A AUID- ORCID: 0000-0002-8017-9754 AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. FAU - Pavon, Francisco Javier AU - Pavon FJ AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. LA - eng PT - Journal Article DEP - 20171106 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Insulin-Like Growth Factor Binding Protein 3) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Alcohol-Related Disorders/*blood MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Case-Control Studies MH - Cross-Sectional Studies MH - Female MH - Humans MH - Insulin-Like Growth Factor Binding Protein 3/blood MH - Insulin-Like Growth Factor I/*metabolism MH - Male MH - Middle Aged MH - Substance Withdrawal Syndrome/*blood PMC - PMC5673472 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2017/11/07 06:00 MHDA- 2017/11/29 06:00 PMCR- 2017/11/06 CRDT- 2017/11/07 06:00 PHST- 2017/07/17 00:00 [received] PHST- 2017/10/23 00:00 [accepted] PHST- 2017/11/07 06:00 [entrez] PHST- 2017/11/07 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] PHST- 2017/11/06 00:00 [pmc-release] AID - PONE-D-17-26748 [pii] AID - 10.1371/journal.pone.0187634 [doi] PST - epublish SO - PLoS One. 2017 Nov 6;12(11):e0187634. doi: 10.1371/journal.pone.0187634. eCollection 2017.