PMID- 29108328
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 45
DP  - 2017 Oct 3
TI  - MMP-3 gene polymorphisms are associated with increased risk of osteoarthritis in 
      Chinese men.
PG  - 79491-79497
LID - 10.18632/oncotarget.18493 [doi]
AB  - Osteoarthritis (OA) is the most common late-onset degenerative joint disease., It 
      is characterized by progressive degradation of articular cartilage. We 
      investigated the association between OA occurrence and single nucleotide 
      polymorphisms (SNPs) in the matrix metalloproteinase-3 (MMP-3) gene involved in 
      the breakdown of extra-cellular matrix proteins. The study included 100 male OA 
      patients and 197 healthy men from the north area of China. Eight MMP-3 SNPs were 
      genotyped. Odds ratios (ORs) with 95% confidence intervals (95%CIs) and 
      multivariate logistic regression analysis were used to assess the association. 
      Multivariate logistic regression analysis was used to identify SNPs that 
      correlated with OA susceptibility. We found that rs639752 (dominant, OR = 2.03, 
      95% CI: 1.03-4.01, P = 0.038; over-dominant, OR = 2.00, 95% CI: 1.03-3.88, P = 
      0.037); rs520540 (dominant, OR = 2.03, 95% CI: 1.03-4.01, P = 0.038; 
      over-dominant, OR = 2.00, 95% CI: 1.03-3.88, P = 0.037); rs602128 (dominant, OR = 
      2.03, 95% CI: 1.03-4.01, P = 0.038; over-dominant, OR = 2.01, 95% CI: 1.03-3.89, 
      P = 0.037); and rs679620 (dominant, OR = 2.03, 95% CI: 1.03-4.01, P = 0.038; 
      over-dominant, OR = 2.04, 95% CI: 1.05-3.96, P = 0.033) were associated with the 
      increased risk of OA. Our results suggest that these SNPs may contribute to OA 
      development, and could serve as molecular markers of OA susceptibility.
FAU - Guo, Wen
AU  - Guo W
AD  - Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Xu, Pengcheng
AU  - Xu P
AD  - Department of Hand Surgery, Hebei province Cangzhou Hospital of integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Jin, Tianbo
AU  - Jin T
AD  - National Engineering Research Center for Miniaturized Detection Systems, School 
      of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
AD  - Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi, China.
FAU - Wang, Jihong
AU  - Wang J
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Fan, Dongsheng
AU  - Fan D
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Hao, Zengtao
AU  - Hao Z
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Ji, Yuntao
AU  - Ji Y
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Jing, Shangfei
AU  - Jing S
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Han, Chaoqian
AU  - Han C
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Du, Jieli
AU  - Du J
AD  - Cangzhou People's Hospitial, Cangzhou, Hebei, China.
FAU - Jiang, Dong
AU  - Jiang D
AD  - Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
FAU - Wen, Shuzheng
AU  - Wen S
AD  - Department of Hand Surgery, Hebei Province Cangzhou Hospital of Integrated 
      Traditional and Western Medicine, Cangzhou, Hebei, China.
FAU - Wang, Jianzhong
AU  - Wang J
AD  - Department of Trauma, Second Affiliated Hospital, Inner Mongolia Medical 
      University, Hohhot, Inner Mongolia Autonomous Region, China.
LA  - eng
PT  - Journal Article
DEP - 20170615
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
EIN - Oncotarget. 2018 Apr 13;9(28):20221. PMID: 29733083
PMC - PMC5668061
OTO - NOTNLM
OT  - MMP-3
OT  - association
OT  - osteoarthritis
OT  - single nucleotide polymorphism
COIS- CONFLICTS OF INTEREST The authors declare no conflict of interest.
EDAT- 2017/11/08 06:00
MHDA- 2017/11/08 06:01
PMCR- 2017/10/03
CRDT- 2017/11/08 06:00
PHST- 2016/12/08 00:00 [received]
PHST- 2017/04/26 00:00 [accepted]
PHST- 2017/11/08 06:00 [entrez]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2017/11/08 06:01 [medline]
PHST- 2017/10/03 00:00 [pmc-release]
AID - 18493 [pii]
AID - 10.18632/oncotarget.18493 [doi]
PST - epublish
SO  - Oncotarget. 2017 Jun 15;8(45):79491-79497. doi: 10.18632/oncotarget.18493. 
      eCollection 2017 Oct 3.