PMID- 29109326
OWN - NLM
STAT- MEDLINE
DCOM- 20180828
LR  - 20201019
IS  - 1526-3711 (Electronic)
IS  - 1526-3711 (Linking)
VI  - 18
IP  - 11
DP  - 2017 Nov 1
TI  - Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in 
      Periodontal Health and Disease in Central Maharashtra (India) Population.
PG  - 1085-1089
AB  - AIM: The incidence and progression of the periodontal disease depend on 
      periodontal microflora and the multifaceted response of the host, and these 
      interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is 
      a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study 
      was the assessment of the periodontal therapy in IL-18 level in periodontal 
      disease and health. MATERIALS AND METHODS: Based on clinical attachment loss 
      (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) 
      patients were divided into three groups: Group I with healthy patients, group II 
      with chronic periodontitis, and group III with posttreatment patients having 
      periodontitis. RESULTS: Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) 
      volume were significantly higher in groups II and III compared with group I. 
      However, there were no significant differences between GI in groups I, II, and 
      III. The total amount of IL-18 in GCF was significantly higher in group II when 
      compared with groups I and III (p < 0.05). CONCLUSION: The present study 
      confirmed that the IL-18 level in GCF was lower in healthy patients, higher in 
      periodontally involved patients, and reduced at baseline, 3 and 6 weeks after 
      nonsurgical periodontal therapy. CLINICAL SIGNIFICANCE: The IL-18 might be 
      hypothetically beneficial in distinguishing health from disease and monitoring 
      periodontal disease activity.
FAU - Mahajani, Monica J
AU  - Mahajani MJ
AD  - Department of Periodontics, Dr. Hedgewar Smruti Rugna Seva Mandal Dental College 
      & Hospital, Hingoli, Maharashtra, India.
FAU - Jadhao, Varsha A
AU  - Jadhao VA
AD  - Department of Dentistry, Government Medical College & Hospital, Akola 
      Maharashtra, India.
FAU - Wankhade, Pooja S
AU  - Wankhade PS
AD  - Department of Oral Medicine and Radiology, VYWS, Amravati's Dental College & 
      Hospital, Amravati Maharashtra, India.
FAU - Samson, Emmanuel
AU  - Samson E
AD  - Department of Conservative and Endodontics, Dr. Hedgewar Smruti Rugna Seva Mandal 
      Dental College & Hospital, Hingoli Maharashtra, India.
FAU - Acharya, Vishwas D
AU  - Acharya VD
AD  - Department of Oral Medicine and Radiology, Dr. Hedgewar Smruti Rugna Seva Mandal 
      Dental College & Hospital, Hingoli Maharashtra, India.
FAU - Tekale, Pawankumar D
AU  - Tekale PD
AD  - Department of Orthodontics, Dr. Rajesh Ramdasji Kambe Dental College & Hospital, 
      Akola, Maharashtra, India, Phone: +919970879100 e-mail: pawan0804@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20171101
PL  - India
TA  - J Contemp Dent Pract
JT  - The journal of contemporary dental practice
JID - 101090552
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gingival Crevicular Fluid/*chemistry
MH  - Humans
MH  - India
MH  - Interleukin-18/*analysis
MH  - Male
MH  - Periodontitis/*immunology/*therapy
OTO - NOTNLM
OT  - Interleukin-18
OT  - Maharashtra population
OT  - Periodontal therapy Periodontitis.
EDAT- 2017/11/08 06:00
MHDA- 2018/08/29 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/11/08 06:00 [entrez]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2018/08/29 06:00 [medline]
AID - 1526-3711-1948 [pii]
AID - 10.5005/jp-journals-10024-2180 [doi]
PST - epublish
SO  - J Contemp Dent Pract. 2017 Nov 1;18(11):1085-1089. doi: 
      10.5005/jp-journals-10024-2180.