PMID- 29109690
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 8
DP  - 2017
TI  - Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in 
      Chinese University Students at Clinical High Risk for Psychosis.
PG  - 209
LID - 10.3389/fpsyt.2017.00209 [doi]
LID - 209
AB  - BACKGROUND: High rates of non-psychotic psychopathological symptoms have been 
      observed in clinical population at clinical high risk (CHR) for psychosis. These 
      comorbid disorders affected the baseline functional level of CHR patients. 
      However, little is known about the comorbid mental disorder in CHR individuals in 
      non-clinical adolescent population. This study aimed to investigate the comorbid 
      mental disorder in non-clinical CHR adolescents and the impact on attenuated 
      psychosis symptoms (APS) as well as clinical outcome. METHODS: The sample 
      consisted of 32 CHR students, who were screened from 2,800 university students. 
      CHR status was evaluated with the Structured Interview of Prodromal Syndromes, 
      comorbid mental disorder diagnoses with the International Neuropsychiatric 
      Interview. RESULTS: In the CHR sample, 46.9% was found at least one non-psychotic 
      comorbid mental disorder. The CHR participants presenting comorbid mental 
      disorder had significantly more severity of APS than those without comorbid 
      mental disorders, and the remission rate at 6-month follow-up is significantly 
      higher in the individuals without comorbid mental disorders at baseline. 
      CONCLUSION: In the non-clinical sample of individuals at CHR, non-psychotic 
      comorbid mental disorders are common and anxiety disorder is most frequent. 
      Copresence of anxiety and/or depression is related to higher level of attenuated 
      psychotic symptoms and unfavorable clinical outcome at 6-month follow-up. 
      Assessment and intervention in anxiety and depression for non-clinical CHR 
      adolescents are suggested.
FAU - Shi, Jingyu
AU  - Shi J
AD  - East Hospital, Tongji University School of Medicine, Shanghai, China.
AD  - Tongji University School of Medicine, Shanghai, China.
FAU - Wang, Lu
AU  - Wang L
AD  - East Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Yao, Yuhong
AU  - Yao Y
AD  - Students Counseling Center, Tongji University, Shanghai, China.
FAU - Su, Na
AU  - Su N
AD  - Tongji University School of Medicine, Shanghai, China.
FAU - Zhan, Chenyu
AU  - Zhan C
AD  - East Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Mao, Ziyu
AU  - Mao Z
AD  - East Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Zhao, Xudong
AU  - Zhao X
AD  - East Hospital, Tongji University School of Medicine, Shanghai, China.
AD  - Tongji University School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20171023
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5660058
OTO - NOTNLM
OT  - anxiety
OT  - clinical high risk
OT  - depression
OT  - longitudinal
OT  - psychosis
OT  - university students
EDAT- 2017/11/08 06:00
MHDA- 2017/11/08 06:01
PMCR- 2017/10/23
CRDT- 2017/11/08 06:00
PHST- 2017/06/23 00:00 [received]
PHST- 2017/10/04 00:00 [accepted]
PHST- 2017/11/08 06:00 [entrez]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2017/11/08 06:01 [medline]
PHST- 2017/10/23 00:00 [pmc-release]
AID - 10.3389/fpsyt.2017.00209 [doi]
PST - epublish
SO  - Front Psychiatry. 2017 Oct 23;8:209. doi: 10.3389/fpsyt.2017.00209. eCollection 
      2017.