PMID- 29110335
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20181010
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 61
IP  - 3
DP  - 2018 Mar
TI  - Correlation between fungal sensitisation in childhood persistent asthma and 
      disease severity.
PG  - 195-200
LID - 10.1111/myc.12726 [doi]
AB  - Fungal sensitisation in adults is associated with severe asthma but prevalence 
      and clinical significance of fungal sensitisation remains unclear in paediatric 
      population. The aim of this study was to study the association of fungal 
      sensitisation with disease severity in children with persistent asthma. One 
      hundred children with persistent asthma in age group 7-15 years, symptom duration 
      >2 years and forced expiratory volume in first second >50% of expected were 
      enrolled. Skin prick test (SPT) to 8 fungal antigens and total serum 
      immunoglobulin E (IgE) were done. Fungal sensitisation was described as positive 
      SPT (wheel diameter more than 3 mm larger than the negative control) to any of 
      the fungal antigens and total serum IgE >200 ng/mL. Seventeen patients showed 
      evidence of fungal sensitisation, of which, 6 demonstrated sensitisation to 
      multiple fungi. 17.6% patients with fungal sensitisation had severe asthma as 
      compared to 2.4% patients without fungal sensitisation (P value .032). 
      Significant increase in family history of allergic comorbidities was noted among 
      patients with fungal sensitisation (47.1% vs 21.7%, P value .03). The most common 
      implicated organism in fungal sensitised patients was Aspergillus flavus (47.1%). 
      The results of this study, a first among Indian children with asthma, suggest 
      that children with fungal sensitisation have more severe asthma as compared to 
      children without fungal sensitisation.
CI  - (c) 2017 Blackwell Verlag GmbH.
FAU - Gupta, Aman
AU  - Gupta A
AUID- ORCID: 0000-0001-5897-7912
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Singh, Meenu
AU  - Singh M
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Chakrabarti, Arunaloke
AU  - Chakrabarti A
AUID- ORCID: 0000-0003-1555-3807
AD  - Department of Medical Microbiology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh, India.
FAU - Mathew, Joseph L
AU  - Mathew JL
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Rawat, Amit
AU  - Rawat A
AD  - Department of Pediatrics, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
LA  - eng
PT  - Journal Article
DEP - 20171122
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
RN  - 0 (Antigens, Fungal)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Antigens, Fungal/immunology
MH  - Aspergillus flavus/chemistry/immunology
MH  - Asthma/immunology/*microbiology/physiopathology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Hypersensitivity
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Skin Tests
OTO - NOTNLM
OT  - Aspergillus species
OT  - childhood persistent asthma
OT  - fungal sensitisation
OT  - serum immunoglobulin E
OT  - severe asthma
OT  - skin prick test
EDAT- 2017/11/08 06:00
MHDA- 2018/10/12 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/05/14 00:00 [received]
PHST- 2017/10/30 00:00 [revised]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2017/11/08 06:00 [entrez]
AID - 10.1111/myc.12726 [doi]
PST - ppublish
SO  - Mycoses. 2018 Mar;61(3):195-200. doi: 10.1111/myc.12726. Epub 2017 Nov 22.