PMID- 29110610
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20180718
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 17
IP  - 4
DP  - 2017 Dec 7
TI  - VEGFR1 Signaling Regulates IL-4-Mediated Arginase 1 Expression in Macrophages.
PG  - 304-311
LID - 10.2174/1566524017666171106114537 [doi]
AB  - BACKGROUND: Macrophages undergo polarization or activation in response to 
      environmental stimuli, an essential process for proper immune response. 
      Meanwhile, excessive activation of macrophages causes autoimmune diseases. It is 
      therefore crucial to prevent over-activation of macrophage in order to maintain 
      the proper immune response. Arginase 1 (Arg-1) plays a critical role in 
      coordinating the immune response by regulating availability of arginine. 
      OBJECTIVE: To understand the mechanism of Arg-1 regulation. METHODS: Real-time 
      PCR and Western Blot analysis were utilized to examine the Arg-1 levels expressed 
      from the VEGFR1-deleted and VEGFR1-TK-deficient bone marrowderived macrophages 
      (BMDMs). RESULTS: The VEGFR1-mediated signaling suppressed IL-4-induced Arg-1 
      expression. Deletion of VEGFR1 resulted in elevated Arg-1 expression and the 
      tyrosine kinase domain of VEGFR1 was required for the suppression. Each of three 
      ligands of VEGFR1, VEGF-A, VEGF-B and PIGF, mediated the inhibition to the 
      similar degree. CONCLUSION: Our findings identified a novel function of the 
      VEGFR1 signaling in avoiding over-expression of Arginase 1 potentially to 
      maintain the proper innate immune response.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Zou, Y
AU  - Zou Y
AD  - The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun 
      Yat-sen University, Guangzhou 510060, China.
FAU - Chen, Q
AU  - Chen Q
AD  - The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun 
      Yat-sen University, Guangzhou 510060, China.
FAU - Ye, Z
AU  - Ye Z
AD  - The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun 
      Yat-sen University, Guangzhou 510060, China.
FAU - Li, X
AU  - Li X
AD  - The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun 
      Yat-sen University, Guangzhou 510060, China.
FAU - Ju, R
AU  - Ju R
AD  - The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun 
      Yat-sen University, Guangzhou 510060, China.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 207137-56-2 (Interleukin-4)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
RN  - EC 3.5.3.1 (Arg1 protein, mouse)
RN  - EC 3.5.3.1 (Arginase)
SB  - IM
MH  - Animals
MH  - Arginase/genetics/*immunology
MH  - Gene Deletion
MH  - Gene Expression Regulation, Enzymologic/*immunology
MH  - Immunity, Innate
MH  - Interleukin-4/genetics/*immunology
MH  - Macrophages/cytology/*metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Signal Transduction/genetics/*immunology
MH  - Vascular Endothelial Growth Factor Receptor-1/genetics/*immunology
OTO - NOTNLM
OT  - Vascular endothelial growth factor receptor 1 (VEGFR1)
OT  - arginase 1 (Arg-1)
OT  - immune response
OT  - interleukin 4 (IL-4)
OT  - macrophage
EDAT- 2017/11/08 06:00
MHDA- 2018/07/19 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/03/18 00:00 [received]
PHST- 2017/10/14 00:00 [revised]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2017/11/08 06:00 [entrez]
AID - CMM-EPUB-86690 [pii]
AID - 10.2174/1566524017666171106114537 [doi]
PST - ppublish
SO  - Curr Mol Med. 2017 Dec 7;17(4):304-311. doi: 10.2174/1566524017666171106114537.