PMID- 29111138
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20181202
IS  - 1873-6254 (Electronic)
IS  - 0001-706X (Linking)
VI  - 178
DP  - 2018 Feb
TI  - KIR-like activating natural killer cell receptors and their association with 
      complicated malaria in north India.
PG  - 55-60
LID - S0001-706X(17)30676-9 [pii]
LID - 10.1016/j.actatropica.2017.10.026 [doi]
AB  - Killer immunoglobulin-like receptors (KIRs) genomic regions have been suggested 
      to influence malaria pathogenesis and infection susceptibility. KIRs are known as 
      activating natural killer (NK) cell receptors, which upon binding to their 
      corresponding human leukocyte antigen (HLA) ligands cause lysis of any infected 
      cell. We have examined the potential association of KIR genes with complicated 
      malaria (CM) among north Indians in this study and further evaluated the KIR 
      receptor-HLA ligand association on the severity of the disease considering the 
      uncomplicated malaria (UCM) subjects as control. Molecular profiling of KIR and 
      HLA was carried out using the PCR-SSP method. Susceptible association was found 
      for individuals possessing KIR2DS2 (OR=1.76, p-value=0.0390), KIR2DL1 (OR=2.87, 
      p-value=0.0005) and KIR2DL3 (OR=2.74, p-value=0.0011) genes with CM. This was 
      supported by the strong linkage disequilibrium observed for 2DS2-2DL2 (D́=0.87, 
      r(2)=0.54) with CM. Whereas the receptor-ligand association has revealed risk 
      association against KIR2DS2-HLAC1 (OR=2.08, p-value=0.0229), KIR2DL3-HLAC1 
      (OR=1.79, p-value=0.0301), and KIR2DL1-HLAC2 (OR=2.10, p-value=0.0175) 
      combinations for complicated malaria. The frequency of different KIR genes are 
      more or less similar to that observed in African population showing not much 
      genetic diversity at KIR level in context to malarial infection. In conclusion, 
      our data indicates KIR gene loci differentially influenced the malarial outcome 
      in north Indians and in particular the KIR2DS2 gene appeared to be associated 
      with disease severity.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Prakash, Swayam
AU  - Prakash S
AD  - Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.
FAU - Ranjan, Prabhat
AU  - Ranjan P
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.
FAU - Ghoshal, Ujjala
AU  - Ghoshal U
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.
FAU - Agrawal, Suraksha
AU  - Agrawal S
AD  - Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India. Electronic address: 
      sur_ksha_agrawal@yahoo.co.in.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20171027
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, Natural Killer Cell)
SB  - IM
MH  - Adult
MH  - Apoptosis/*immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Variation
MH  - Genotype
MH  - Histocompatibility Antigens Class I/*genetics/*therapeutic use
MH  - Humans
MH  - India
MH  - Malaria/*therapy
MH  - Male
MH  - Middle Aged
MH  - Receptors, KIR/*genetics/*immunology
MH  - Receptors, Natural Killer Cell/*genetics/*immunology
OTO - NOTNLM
OT  - Complicated malaria
OT  - Genetic association
OT  - Killer immunoglobulin like receptor (KIR)
OT  - Plasmodium falciparum
OT  - Polymerase chain reaction-Sequence specific primer (PCR-SSP)
EDAT- 2017/11/08 06:00
MHDA- 2018/06/26 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/06/05 00:00 [received]
PHST- 2017/10/19 00:00 [revised]
PHST- 2017/10/26 00:00 [accepted]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/11/08 06:00 [entrez]
AID - S0001-706X(17)30676-9 [pii]
AID - 10.1016/j.actatropica.2017.10.026 [doi]
PST - ppublish
SO  - Acta Trop. 2018 Feb;178:55-60. doi: 10.1016/j.actatropica.2017.10.026. Epub 2017 
      Oct 27.