PMID- 2911127
OWN - NLM
STAT- MEDLINE
DCOM- 19890223
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 63
IP  - 2
DP  - 1989 Feb
TI  - Transactivation of human immunodeficiency virus promoter by human herpesvirus 6.
PG  - 970-3
AB  - Patients with acquired immunodeficiency syndrome (AIDS) are often infected with a 
      number of other heterologous viruses in addition to the initial human 
      immunodeficiency virus (HIV) infection, and these agents could act as potential 
      reactivating agents of latent HIV. A new antigenically distinct herpesvirus, 
      designated human herpesvirus 6 (HHV-6), has recently been isolated from patients 
      with AIDS and has been shown to infect a number of different human cells, 
      specifically human T cells, B cells, and glial cells. Since these are some of the 
      same cells that harbor the AIDS virus, it is quite important to determine any 
      interaction between this new herpesvirus and HIV. In this report, we demonstrate 
      that HHV-6 can trans-activate the HIV promoter in human T-cell lines as measured 
      by the expression of the bacterial gene chloramphenicol acetyltransferase. This 
      indicates that stimulation of HIV gene expression by HHV-6 could play a role in 
      HIV pathogenesis.
FAU - Horvat, R T
AU  - Horvat RT
AD  - Department of Microbiology, University of Kansas, Lawrence 66045.
FAU - Wood, C
AU  - Wood C
FAU - Balachandran, N
AU  - Balachandran N
LA  - eng
GR  - AI24115/AI/NIAID NIH HHS/United States
GR  - AI24224/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/microbiology
MH  - *Gene Expression Regulation
MH  - *Genes, Viral
MH  - HIV/genetics/*growth & development
MH  - Herpesviridae/isolation & purification/*physiology
MH  - Humans
MH  - *Promoter Regions, Genetic
MH  - Recombinant Fusion Proteins/biosynthesis
MH  - Virus Activation
PMC - PMC247777
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
PMCR- 1989/02/01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
PHST- 1989/02/01 00:00 [pmc-release]
AID - 10.1128/JVI.63.2.970-973.1989 [doi]
PST - ppublish
SO  - J Virol. 1989 Feb;63(2):970-3. doi: 10.1128/JVI.63.2.970-973.1989.