PMID- 29111278
OWN - NLM
STAT- MEDLINE
DCOM- 20180503
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 135
DP  - 2018 Jan
TI  - The association of inflammatory markers and periodontal indexes with the risk of 
      coronary heart disease in Chinese patients with type 2 diabetes mellitus.
PG  - 37-44
LID - S0168-8227(17)31337-2 [pii]
LID - 10.1016/j.diabres.2017.10.008 [doi]
AB  - OBJECTIVES: The present study was designed to investigate the association of four 
      inflammatory markers and five periodontal indexes with the risk of coronary heart 
      disease (CHD) in 131 patients with type 2 diabetes mellitus (T2DM). METHODS: All 
      subjects were inpatients, including 63 T2DM patients with comorbid CHD ("cases") 
      and 68 T2DM patients without CHD ("controls"). The diagnosis of CHD is based on 
      coronary angiography. RESULTS: Peripheral blood concentrations of high 
      sensitivity C-reactive protein (hs-CRP) (11.51 vs. 10.39 mg/L), leptin (24.60 vs. 
      21.22 ng/L) and visfatin (65.92 vs. 57.62 ng/L) were significantly higher in 
      cases than in controls (P = .033, 0.041 and 0.041, respectively). The levels of 
      three periodontal indexes - probing pocket depth, attachment loss (AL) and sulcus 
      bleeding index, were significantly higher in cases than in controls, especially 
      for periodontal AL (3.60 mm vs. 3.29 mm, P = .002). A Forward logistic regression 
      was performed for selection, and specifically hs-CRP, leptin, visfatin and 
      periodontal AL were found to be associated with the significant risk of CHD (odds 
      ratio: 1.16, 1.07, 1.03 and 2.04; P = .025, .022, .022 and .010, respectively). 
      Importantly, the benefits of inflammatory markers and periodontal indexes over 
      basic risk factors were significant (likelihood ratio test) and obvious (decision 
      curve analysis). A nomogram was delineated based on significant variables, and it 
      had good accuracy (C-index: 0.801, P < .001). CONCLUSIONS: Our findings support 
      the significant contribution of inflammatory markers and periodontal indexes to 
      the pathogenesis of CHD in T2DM. Specifically, hs-CRP, leptin, visfatin and 
      periodontal AL were identified as significant contributors.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Chen, Ling
AU  - Chen L
AD  - Department of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China; Teaching and Research Section of Stomatology, 
      The First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, 
      China.
FAU - Wei, Bin
AU  - Wei B
AD  - Department of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China; Teaching and Research Section of Stomatology, 
      The First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, 
      China.
FAU - Xu, Liang
AU  - Xu L
AD  - Department of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China; Teaching and Research Section of Stomatology, 
      The First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, 
      China.
FAU - Wu, Yun
AU  - Wu Y
AD  - Department of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China; Teaching and Research Section of Stomatology, 
      The First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, 
      China. Electronic address: wincls1080@163.com.
LA  - eng
PT  - Journal Article
DEP - 20171028
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Asian People
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Coronary Disease/blood/*etiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Humans
MH  - Inflammation/*complications
MH  - Male
MH  - Middle Aged
MH  - *Periodontal Index
MH  - Risk Factors
OTO - NOTNLM
OT  - Coronary heart disease
OT  - Inflammatory marker
OT  - Periodontal index
OT  - Risk prediction
OT  - Type 2 diabetes mellitus
EDAT- 2017/11/08 06:00
MHDA- 2018/05/04 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/08/14 00:00 [received]
PHST- 2017/09/29 00:00 [revised]
PHST- 2017/10/11 00:00 [accepted]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2018/05/04 06:00 [medline]
PHST- 2017/11/08 06:00 [entrez]
AID - S0168-8227(17)31337-2 [pii]
AID - 10.1016/j.diabres.2017.10.008 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Jan;135:37-44. doi: 10.1016/j.diabres.2017.10.008. 
      Epub 2017 Oct 28.