PMID- 29111883
OWN - NLM
STAT- MEDLINE
DCOM- 20200115
LR  - 20200115
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 25
IP  - 1
DP  - 2019 Jan
TI  - Multiple sclerosis and HLA genotypes: A possible influence on brain atrophy.
PG  - 23-30
LID - 10.1177/1352458517739989 [doi]
AB  - BACKGROUND: The strongest genetic determinant for multiple sclerosis (MS) is 
      located at the human leukocyte antigen (HLA) class II DRB1 and DQB1 loci. 
      OBJECTIVES: To investigate the possible role of predisposing HLA genotypes in 
      determining brain atrophy. METHODS: HLA genotypes were categorized as high risk 
      (two predisposing haplotypes) or medium/low risk (one or no predisposing 
      haplotypes). Patients underwent a brain magnetic resonance imaging (MRI) study 
      and volumes of white matter (WM), gray matter (GM), and whole brain (WB) were 
      estimated with SIENAX. Longitudinal atrophy was also assessed with SIENA. 
      RESULTS: The study included 240 MS patients. In 51/240 (21%) subjects, a 
      high-risk HLA genotype was observed, while medium- and low-risk HLA genotypes 
      were 109/240 (45%) and 80/240 (34%), respectively. Multiple regression analysis 
      found that the high-risk HLA genotype was associated with significant reduction 
      in WB ( p = 0.02) and GM ( p = 0.03) volumes compared with the medium-/low-risk 
      HLA genotypes, independently from MS clinical features. The longitudinal study 
      included 60 patients and showed a brain volume loss of -0.79% in high-risk HLA 
      genotype group versus -0.56% in low-risk HLA genotype. CONCLUSION: Our results 
      suggest an influence of HLA genotype on WB and GM atrophy. Further investigations 
      are necessary to confirm these findings.
FAU - Lorefice, Lorena
AU  - Lorefice L
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Fenu, Giuseppe
AU  - Fenu G
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Sardu, Claudia
AU  - Sardu C
AD  - Unit of Epidemiology, Department of Medical Science and Public Health, University 
      of Cagliari, Cagliari, Italy.
FAU - Frau, Jessica
AU  - Frau J
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Coghe, Giancarlo
AU  - Coghe G
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Costa, Gianna
AU  - Costa G
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Schirru, Lucia
AU  - Schirru L
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Secci, Maria Antonietta
AU  - Secci MA
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Sechi, Vincenzo
AU  - Sechi V
AD  - Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy.
FAU - Barracciu, Maria Antonietta
AU  - Barracciu MA
AD  - Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy.
FAU - Marrosu, Maria Giovanna
AU  - Marrosu MG
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
FAU - Cocco, Eleonora
AU  - Cocco E
AD  - Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Cagliari, 
      Italy/Department of Medical Science and Public Health, University of Cagliari, 
      Cagliari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20171107
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Atrophy
MH  - Brain
MH  - Female
MH  - Gray Matter/diagnostic imaging/*pathology
MH  - HLA-D Antigens/*genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Italy
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnostic imaging/*genetics/*pathology
MH  - White Matter/diagnostic imaging/*pathology
OTO - NOTNLM
OT  - HLA genotypes
OT  - Multiple sclerosis
OT  - Sardinia
OT  - brain atrophy
OT  - gray matter
OT  - quantitative MRI
EDAT- 2017/11/08 06:00
MHDA- 2020/01/16 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2020/01/16 06:00 [medline]
PHST- 2017/11/08 06:00 [entrez]
AID - 10.1177/1352458517739989 [doi]
PST - ppublish
SO  - Mult Scler. 2019 Jan;25(1):23-30. doi: 10.1177/1352458517739989. Epub 2017 Nov 7.